ER stress of cancer cell SCC25 induces LOX-1-expressed immunosuppressive neutrophils
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Oncology"
DOI: 10.1093/annonc/mdz452.025
Abstract: Abstract Background Immunosuppressive neutrophils with surface expression of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) existed at both tumor sites and blood in patients with head and neck squamous cell carcinoma (HNSCC). Their immunosuppressive activities were… read more here.
Keywords: cell; scc25; stress; immunosuppressive neutrophils ... See more keywords
Blocking immunosuppressive neutrophils deters pY696-EZH2–driven brain metastases
Sign Up to like & getrecommendations! Published in 2020 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aaz5387
Abstract: G-CSF antibodies and immune checkpoint blockade with Src inhibitors block neutrophil infiltration to impede pY696-EZH2–driven brain metastasis. Closing the door to neutrophils Brain metastasis, which occurs in many cancers, is an ominous finding that remains… read more here.
Keywords: brain metastases; py696 ezh2; brain; brain metastasis ... See more keywords