TMIC-31. Store-operated calcium channels promote glioblastoma-associated vascular cell-induced microglia polarization towards an immunosuppressive phenotype
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DOI: 10.1093/neuonc/noaf201.1786
Abstract: Glioblastoma (GBM) is characterized by extensive neovascularization and a highly immunosuppressive microenvironment. GBM-associated microglia and macrophages (GAMs) constitute the major immune cell population and are key drivers of tumor growth and immunosuppression. However, the mechanisms… read more here.
Keywords: associated vascular; store operated; polarization; immunosuppressive phenotype ... See more keywords
SPI1 upregulated LILRB2 to enhance the immunosuppressive phenotype of LPS-tolerant macrophages by inhibiting TLR8-mediated MyD88/NF-κB signaling
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DOI: 10.1186/s13062-025-00669-0
Abstract: In sepsis, immunosuppression is commonly observed as lipopolysaccharide (LPS) tolerance in macrophages. Leukocyte immunoglobulin-like receptor B2 (LILRB2) is an inhibitory receptor on immune cells that may play a crucial role in the immunosuppressive phenotype of… read more here.
Keywords: lps tolerant; tolerant macrophages; immunosuppressive phenotype; phenotype lps ... See more keywords