Reducing the immunosuppressive tumor microenvironment enhances photoimmunotherapy efficacy
Sign Up to like & getrecommendations! Published in 2021 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2021.103351
Abstract: Photodynamic therapy (PDT) is a treatment that utilizes photosensitizers and light of a specific wavelength to kill cancer cells [1]. Additionally, the therapy may offer long term protection through activation of antitumor immune responses. Although… read more here.
Keywords: immunosuppressive tumor; treatment; cancer; tumor microenvironment ... See more keywords
Metal-Phenolic Network-Enabled Lactic Acid Consumption Reverses Immunosuppressive Tumor Microenvironment for Sonodynamic Therapy.
Sign Up to like & getrecommendations! Published in 2021 at "ACS nano"
DOI: 10.1021/acsnano.1c08026
Abstract: Nanomedicine has revolutionized cancer therapeutic strategies but has not completely changed the outcomes of tricky tumors that evolve a sophisticated immunosuppressive tumor microenvironment (TME) such as acidification. Here, a metal-phenolic network-based nanocomplex embedded with lactate… read more here.
Keywords: metal phenolic; immunosuppressive tumor; phenolic network; sonodynamic therapy ... See more keywords
Nanodrug regulates lactic acid metabolism to reprogram the immunosuppressive tumor microenvironment for enhanced cancer immunotherapy.
Sign Up to like & getrecommendations! Published in 2022 at "Biomaterials science"
DOI: 10.1039/d2bm00650b
Abstract: A majority of cancers fail to respond to immunotherapy due to the immunosuppressive tumor microenvironment (TME), and metabolic regulation of the TME has been a promising strategy to improve immunotherapy. Lactate is a key metabolic… read more here.
Keywords: immunotherapy; tumor microenvironment; immunosuppressive tumor; lactic acid ... See more keywords
Abstract A079: Glutamine antagonist prodrug JHU083 reprograms immunosuppressive tumor-associated macrophages to drive tumor immunity in urologic cancers
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.prca2023-a079
Abstract: Tumor metabolism is emerging as a regulator of immune mediated anti-tumor responses. Previously, we reported increased immunosuppressive tumor-associated macrophages (TAMs) infiltration with disease progression in prostate adenocarcinoma (PCa).1 Glutamine metabolism has been implicated in metastatic… read more here.
Keywords: anti tumor; immunosuppressive tumor; jhu083; tumor ... See more keywords
Abstract IA08: Engineering T cells to resist and convert immunosuppressive tumor microenvironments
Sign Up to like & getrecommendations! Published in 2018 at "Cancer immunology research"
DOI: 10.1158/2326-6074.tumimm17-ia08
Abstract: A major challenge in adoptive T-cell therapy for solid tumors is the harsh immunosuppressive tumor microenvironment. Soluble factors such as transforming growth factor beta (TGF-β) play key roles in tumor immune evasion. Here, we report… read more here.
Keywords: resist convert; immunosuppressive tumor; cells resist; engineering cells ... See more keywords
Injectable Hydrogel as a Unique Platform for Antitumor Therapy Targeting Immunosuppressive Tumor Microenvironment
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.832942
Abstract: Cancer immunotherapy can boost the immune response of patients to eliminate tumor cells and suppress tumor metastasis and recurrence. However, immunotherapy resistance and the occurrence of severe immune-related adverse effects are clinical challenges that remain… read more here.
Keywords: targeting immunosuppressive; unique platform; tumor microenvironment; immunosuppressive tumor ... See more keywords
Immunosuppressive Tumor Microenvironment and Immunotherapy of Epstein–Barr Virus-Associated Malignancies
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14051017
Abstract: The Epstein–Barr virus (EBV) can cause different types of cancer in human beings when the virus infects different cell types with various latent patterns. EBV shapes a distinct and immunosuppressive tumor microenvironment (TME) to its… read more here.
Keywords: associated malignancies; epstein barr; immunosuppressive tumor; virus ... See more keywords