A Metabolic Reprogramming Amino Acid Polymer as an Immunosurveillance Activator and Leukemia Targeting Drug Carrier for T‐Cell Acute Lymphoblastic Leukemia
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202104134
Abstract: Abstract Compromised immunosurveillance leads to chemotherapy resistance and disease relapse of hematological malignancies. Amino acid metabolism regulates immune responses and cancer; however, a druggable amino acid metabolite to enhance antitumor immunosurveillance and improve leukemia targeting‐therapy… read more here.
Keywords: immunosurveillance; cell; leukemia; metabolic reprogramming ... See more keywords
The interplay between innate and adaptive immunity in cancer shapes the productivity of cancer immunosurveillance
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3mir0320-475r
Abstract: The immune system is a vital determinant of cancer and shapes its trajectory. Notably, the immune reaction to cancer harbors dual potential for suppressing or promoting cancer development and progression. This polarity of the immune… read more here.
Keywords: immunosurveillance; cancer shapes; immunity; cancer ... See more keywords
Cancer Immunosurveillance by T Cells.
Sign Up to like & getrecommendations! Published in 2019 at "International review of cell and molecular biology"
DOI: 10.1016/bs.ircmb.2018.08.001
Abstract: Cancer immunotherapy is based on the ability of the immune system to recognize tumors as foreign tissue. The idea of cancer immunosurveillance was first conceived over a century ago but remained controversial through much of… read more here.
Keywords: immunosurveillance; biology; cancer immunosurveillance; cancer ... See more keywords
Cancer-Induced Endoplasmic Reticulum Stress in T Cells Subverts Immunosurveillance.
Sign Up to like & getrecommendations! Published in 2018 at "Cell metabolism"
DOI: 10.1016/j.cmet.2018.11.003
Abstract: Compelling evidence indicates that tumors may evade immunosurveillance by subverting the metabolism of immune cells. In a recent paper in Nature, Song et al. (2018) demonstrate that ovarian cancers activate IRE1α-XBP1 signaling within CD4+ T lymphocytes, thereby… read more here.
Keywords: induced endoplasmic; endoplasmic reticulum; reticulum stress; stress cells ... See more keywords
Ribosomal Proteins Regulate MHC Class I Peptide Generation for Immunosurveillance.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular cell"
DOI: 10.1016/j.molcel.2018.12.020
Abstract: The MHC class I antigen presentation system enables T cell immunosurveillance of cancers and viruses. A substantial fraction of the immunopeptidome derives from rapidly degraded nascent polypeptides (DRiPs). By knocking down each of the 80 ribosomal… read more here.
Keywords: immunosurveillance; peptide generation; mhc class; ribosomal proteins ... See more keywords
Effects of caloric restriction on immunosurveillance, microbiota and cancer cell phenotype: possible implications for cancer treatment.
Sign Up to like & getrecommendations! Published in 2020 at "Seminars in cancer biology"
DOI: 10.1016/j.semcancer.2020.11.017
Abstract: Fasting, caloric restriction and foods or compounds mimicking the biological effects of caloric restriction, known as caloric restriction mimetics, have been associated with a lower risk of age-related diseases, including cardiovascular diseases, cancer and cognitive… read more here.
Keywords: effects caloric; restriction; microbiota; caloric restriction ... See more keywords
Protein-Cloaked Nanoparticles for Enhanced Cellular Association and Controlled Pathophysiology via Immunosurveillance Escape.
Sign Up to like & getrecommendations! Published in 2021 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.1c20719
Abstract: Weak interactions play an important role in soft corona (SC) formation and thus help in evaluating the biological fate of the nanoparticles (NPs). Preadsorption of specific proteins on the NP surface, leading to SC formation,… read more here.
Keywords: protein cloaked; cellular association; pathophysiology; immunosurveillance ... See more keywords
Cellular senescence enhances adaptive anticancer immunosurveillance
Sign Up to like & getrecommendations! Published in 2022 at "Oncoimmunology"
DOI: 10.1080/2162402x.2022.2154115
Abstract: ABSTRACT Cancer therapy often induces senescence in some cancer cells. Senescent cells, due to their profoundly altered biology, may conceivably interact with the adaptive immune system in novel ways that may boost cancer immunosurveillance, triggering… read more here.
Keywords: immunosurveillance; senescence enhances; senescence; cellular senescence ... See more keywords
Immunogenic stress and death of cancer cells: Contribution of antigenicity vs adjuvanticity to immunosurveillance
Sign Up to like & getrecommendations! Published in 2017 at "Immunological Reviews"
DOI: 10.1111/imr.12582
Abstract: Cancer cells are subjected to constant selection by the immune system, meaning that tumors that become clinically manifest have managed to subvert or hide from immunosurveillance. Immune control can be facilitated by induction of autophagy,… read more here.
Keywords: adjuvanticity; cancer cells; cancer; immunosurveillance ... See more keywords
Metabolic features of cancer cells impact immunosurveillance
Sign Up to like & getrecommendations! Published in 2021 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-002362
Abstract: Background Tumors rewire their metabolism to achieve robust anabolism and resistance against therapeutic interventions like cisplatin treatment. For example, a prolonged exposure to cisplatin causes downregulation of pyridoxal kinase (PDXK), the enzyme that generates the… read more here.
Keywords: cell; infiltration; cisplatin; cancer cells ... See more keywords
Cancer cell-autonomous overactivation of PARP1 compromises immunosurveillance in non-small cell lung cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-004280
Abstract: Background High activity of poly(ADP-ribose) polymerase-1 (PARP1) in non-small cell lung cancer (NSCLC) cells leads to an increase in immunohistochemically detectable PAR, correlating with poor prognosis in patients with NSCLC, as well as reduced tumor… read more here.
Keywords: immunosurveillance; lung cancer; cell; parp1 ... See more keywords