Spatial multi-omics revealed the impact of tumor ecosystem heterogeneity on immunotherapy efficacy in patients with advanced non-small cell lung cancer treated with bispecific antibody
Sign Up to like & getrecommendations! Published in 2023 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-006234
Abstract: Background Immunotherapy for malignant tumors has made great progress, but many patients do not benefit from it. The complex intratumoral heterogeneity (ITH) hindered the in-depth exploration of immunotherapy. Conventional bulk sequencing has masked intratumor complexity,… read more here.
Keywords: multi omics; immunotherapy; efficacy; immunotherapy efficacy ... See more keywords
Midkine Promotes Immunosuppression and Reduces Immunotherapy Efficacy.
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DOI: 10.1158/2159-8290.cd-rw2020-157
Abstract: Expression of MDK, encoding the growth factor midkine, led to immunotherapy resistance in melanoma. read more here.
Keywords: midkine promotes; promotes immunosuppression; immunotherapy efficacy; midkine ... See more keywords
Immunotherapy efficacy and gender: discovery in precision medicine.
Sign Up to like & getrecommendations! Published in 2018 at "Translational lung cancer research"
DOI: 10.21037/tlcr.2018.08.05
Abstract: Immunotherapy is transforming the care of cancer. In the past five years, checkpoint blockade agents targeting the PD-1/PD-L1 checkpoint (e.g., nivolumab, pembrolizumab) have garnered FDA approvals in diverse indications including melanoma, non-small cell lung cancer… read more here.
Keywords: medicine; discovery precision; immunotherapy; efficacy gender ... See more keywords
Predictive biomarkers for immunotherapy efficacy in non-small-cell lung cancer: current status and future perspectives.
Sign Up to like & getrecommendations! Published in 2020 at "Biomarkers in medicine"
DOI: 10.2217/bmm-2020-0310
Abstract: In recent years, immune checkpoint inhibitors have rapidly changed treatment paradigms and have been pivotal for the treatment of advanced NSCLC patients. However, many patients don't respond to immunotherapy, and toxicities are a concern. Mounting… read more here.
Keywords: future perspectives; biomarkers immunotherapy; efficacy; efficacy non ... See more keywords
Serum neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in prognosticating immunotherapy efficacy.
Sign Up to like & getrecommendations! Published in 2020 at "Immunotherapy"
DOI: 10.2217/imt-2020-0105
Abstract: Aim: To examine neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in prognosticating immunotherapy efficacy. Methods: A retrospective study of 156 patients with metastatic melanoma and non-small-cell lung cancer on PD-1 inhibitors. Results: Baseline NLR ≥5 was… read more here.
Keywords: immunotherapy efficacy; lymphocyte ratio; ratio; neutrophil lymphocyte ... See more keywords
ASF1B is a Promising Prognostic Biomarker and Correlates With Immunotherapy Efficacy in Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.842351
Abstract: Background: Anti-silencing function 1B (ASF1B), a histone H3-H4 chaperone, is crucial for S-phase progression and cell proliferation. Recent studies have shown that ASF1B may be used as a new proliferation marker for cancer prognosis. However,… read more here.
Keywords: hepatocellular carcinoma; expression; asf1b; immunotherapy efficacy ... See more keywords
Brain Metastases Status and Immunotherapy Efficacy in Advanced Lung Cancer: A Systematic Review and Meta-Analysis
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DOI: 10.3389/fimmu.2021.669398
Abstract: Background Brain metastases (BMs) indicate poor outcomes and are commonly excluded in immunotherapy clinical trials in advanced lung cancer; moreover, the effect of BM status on immunotherapy efficacy is inconsistent and inconclusive. Therefore, we conducted… read more here.
Keywords: status; immunotherapy efficacy; immunotherapy; lung cancer ... See more keywords
Evaluation of immunotherapy efficacy in gynecologic cancer
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DOI: 10.3389/fimmu.2023.1061761
Abstract: Various immunotherapies have demonstrated remarkable success over the past few decades, and have been approved for the treatment of different cancer types. However, patient responses to immunotherapy are variable, and approximately 50% of cases are… read more here.
Keywords: evaluation immunotherapy; efficacy gynecologic; gynecologic cancer; immunotherapy efficacy ... See more keywords
The Tango between Cancer-Associated Fibroblasts (CAFs) and Immune Cells in Affecting Immunotherapy Efficacy in Pancreatic Cancer
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DOI: 10.3390/ijms24108707
Abstract: The lack of response to therapy in pancreatic ductal adenocarcinoma (PDAC) patients has contributed to PDAC having one of the lowest survival rates of all cancer types. The poor survival of PDAC patients urges the… read more here.
Keywords: associated fibroblasts; immunotherapy efficacy; cancer associated; fibroblasts cafs ... See more keywords