Uncovering key targets of success for immunotherapy in pancreatic cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Expert opinion on therapeutic targets"
DOI: 10.1080/14728222.2021.2010044
Abstract: INTRODUCTION Despite available treatment options, pancreatic ductal adenocarcinoma (PDAC) is frequently lethal. Recent immunotherapy strategies have failed to yield any notable impact. Therefore, research is focussed on unearthing new drug targets and therapeutic strategies to… read more here.
Keywords: immunotherapy; uncovering key; immunotherapy pancreatic; key targets ... See more keywords
Combination immunotherapy for pancreatic cancer: challenges and future considerations
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Clinical Immunology"
DOI: 10.1080/1744666x.2022.2120471
Abstract: ABSTRACT Introduction Immune checkpoint inhibitors (ICI) have not yielded significant efficacy in pancreatic ductal adenocarcinoma (PDA), despite the role of the innate and adaptive immune systems on progression and survival. However, recently identified pathways have… read more here.
Keywords: immunotherapy pancreatic; combination immunotherapy; pancreatic cancer; challenges future ... See more keywords
Immunotherapy for Pancreatic Cancer: More Than Just a Gut Feeling.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-18-0123
Abstract: Development of pancreatic cancer in spontaneous murine models is associated with enrichment of specific strains of gut and intratumoral bacteria that induce a tolerogenic immunosuppressive microenvironment favoring cancer progression and resistance to immunotherapies. Ablation of… read more here.
Keywords: cancer gut; gut feeling; pancreatic cancer; immunotherapy pancreatic ... See more keywords
Immunotherapy in pancreatic cancer-an emerging role: a narrative review.
Sign Up to like & getrecommendations! Published in 2022 at "Chinese clinical oncology"
DOI: 10.21037/cco-21-174
Abstract: BACKGROUND AND OBJECTIVE Immunotherapy is the fastest growing branch in oncology that have already revolutionized the treatment of few solid cancers. The number of immunotherapy trials for pancreatic cancer (PC) is growing but the vast… read more here.
Keywords: oncology; immunotherapy pancreatic; immunotherapy; review ... See more keywords
Rational combinations of immunotherapy for pancreatic ductal adenocarcinoma.
Sign Up to like & getrecommendations! Published in 2017 at "Chinese clinical oncology"
DOI: 10.21037/cco.2017.06.04
Abstract: The complex interaction between the immune system, the tumor and the microenvironment in pancreatic ductal adenocarcinoma (PDA) leads to the resistance of PDA to immunotherapy. To overcome this resistance, combination immunotherapy is being proposed. However,… read more here.
Keywords: combinations immunotherapy; rational combinations; immunotherapy pancreatic; pancreatic ductal ... See more keywords
Identification of CKS1B as a prognostic indicator and a predictive marker for immunotherapy in pancreatic cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1052768
Abstract: As a regulatory subunit of cyclin kinase, CKS1B promotes cancer development and is associated with poor prognosis in multiple cancer patients. However, the intrinsic role of CKS1B in pancreatic cancer remains elusive. In our research,… read more here.
Keywords: immunotherapy pancreatic; pancreatic cancer; cks1b; cks1b expression ... See more keywords
The Role of Immunotherapy in Pancreatic Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Current Oncology"
DOI: 10.3390/curroncol29100541
Abstract: Pancreatic adenocarcinoma remains one of the most lethal cancers globally, with a significant need for improved therapeutic options. While the recent breakthroughs of immunotherapy through checkpoint inhibitors have dramatically changed treatment paradigms in other malignancies… read more here.
Keywords: pancreatic cancer; role immunotherapy; immunotherapy pancreatic; cancer ... See more keywords
Progress and prospects for use of cellular immunotherapy in pancreatic cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cancer Research and Therapeutics"
DOI: 10.4103/jcrt.jcrt_976_21
Abstract: Pancreatic cancer (PC) is a highly malignant tumor with an increasing incidence rate in recent years. Because pancreatic cancer has an insidious onset, unknown pathophysiology, and poor prognosis, the overall survival rate of pancreatic cancer… read more here.
Keywords: immunotherapy pancreatic; progress prospects; pancreatic cancer; cellular immunotherapy ... See more keywords