Combining immunotherapy and radiotherapy for the STAR treatment
Sign Up to like & getrecommendations! Published in 2019 at "Nature Reviews Clinical Oncology"
DOI: 10.1038/s41571-019-0277-2
Abstract: In the past few years, efforts have been made to combine two approaches — immune-checkpoint inhibition and locally ablative radiation therapy — to treat patients with metastatic non-small-cell lung cancer. Herein we discuss the implications… read more here.
Keywords: star treatment; radiotherapy star; immunotherapy radiotherapy; combining immunotherapy ... See more keywords
D-mannose facilitates immunotherapy and radiotherapy of triple-negative breast cancer via degradation of PD-L1
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2114851119
Abstract: Significance PD-L1 is well known as an immune checkpoint molecule, which suppresses immune surveillance through binding to its receptor PD-1. Intracellular PD-L1 can also protect messenger RNAs of several DNA damage repair–related genes from degradation… read more here.
Keywords: immunotherapy radiotherapy; breast cancer; tnbc; degradation ... See more keywords
Clinical evidence for synergy between immunotherapy and radiotherapy (SITAR)
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Imaging and Radiation Oncology"
DOI: 10.1111/1754-9485.13441
Abstract: Previous preclinical and clinical trials have shown promising antitumour activity and toxicity profile when employing the ‘Synergy between Immunotherapy and Radiotherapy’ (SITAR) strategy. Approximately, one in seven radiation therapy studies currently recruiting is investigating SITAR.… read more here.
Keywords: immunotherapy; synergy immunotherapy; immunotherapy radiotherapy; radiotherapy sitar ... See more keywords
Harnessing and Optimizing the Interplay between Immunotherapy and Radiotherapy to Improve Survival Outcomes
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cancer Research"
DOI: 10.1158/1541-7786.mcr-17-0743
Abstract: In the past, radiotherapy was primarily used to control local disease, but recent technological advances in accurate, high-dose ionizing radiation (IR) delivery have not only increased local tumor control but in some cases reduced metastatic… read more here.
Keywords: radiotherapy; harnessing optimizing; immunotherapy radiotherapy; optimizing interplay ... See more keywords
Combining immunotherapy and radiotherapy in hepatocellular carcinoma: the importance of irradiated tumor burden and the possible role of a low dose radiotherapy induction strategy
Sign Up to like & getrecommendations! Published in 2023 at "Translational Cancer Research"
DOI: 10.21037/tcr-23-192
Abstract: disease, compared to only 14% in the dual-ICI arm. This is particularly important for this trial because only intrahepatic disease was irradiated. Furthermore, the maximum GTV was mostly restricted to 100 cc and in the… read more here.
Keywords: immunotherapy radiotherapy; tumor burden; radiotherapy; combining immunotherapy ... See more keywords
Effective Combinations of Immunotherapy and Radiotherapy for Cancer Treatment
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.809304
Abstract: Though single tumor immunotherapy and radiotherapy have significantly improved the survival rate of tumor patients, there are certain limitations in overcoming tumor metastasis, recurrence, and reducing side effects. Therefore, it is urgent to explore new… read more here.
Keywords: immunotherapy radiotherapy; radiotherapy; tumor immunotherapy; treatment ... See more keywords
The Current and Future Promises of Combination Radiation and Immunotherapy for Genitourinary Cancers
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DOI: 10.3390/cancers15010127
Abstract: Simple Summary Contemporary immunotherapy agents have recently been approved for use in genitourinary malignancies. Combining immunotherapy with radiotherapy may have a synergistic effect in treating bladder and prostate cancer. This article reviews the available data… read more here.
Keywords: bladder; immunotherapy; immunotherapy radiotherapy; combination ... See more keywords