Single-cell analysis reveals fibroblast clusters linked to immunotherapy resistance in cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-19-1384
Abstract: A subset of Cancer-Associated Fibroblasts (FAP+/CAF-S1) mediates immunosuppression in breast cancers (BC), but its heterogeneity and its impact on immunotherapy response remain unknown. Here, we identify 8 CAF-S1 clusters by analyzing more than 19000 single… read more here.
Keywords: single cell; caf; immunotherapy resistance; resistance ... See more keywords
Entinostat Helps Thwart Immunotherapy Resistance.
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DOI: 10.1158/2159-8290.cd-nb2019-048
Abstract: Findings from the ENCORE-601 trial's melanoma cohort show that the experimental HDAC inhibitor entinostat is well tolerated and, together with pembrolizumab, induces durable responses in patients whose disease has progressed on PD-1 blockade alone. read more here.
Keywords: entinostat helps; immunotherapy resistance; thwart immunotherapy; helps thwart ... See more keywords
Abstract PR08: Metabolic adaptations establish immunotherapy resistance in melanoma
Sign Up to like & getrecommendations! Published in 2018 at "Cancer immunology research"
DOI: 10.1158/2326-6074.tumimm17-pr08
Abstract: Background: Despite the success of T-cell checkpoint blockade antibodies in treating an array of cancers, the majority of patients still fail to respond to these therapies, or respond transiently and then relapse. The molecular mechanisms… read more here.
Keywords: melanoma; checkpoint blockade; immunotherapy; immunotherapy resistance ... See more keywords
Immunotherapy Resistance in Glioblastoma
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2021.750675
Abstract: Glioblastoma is the most common malignant primary brain tumor in adults. Despite treatment consisting of surgical resection followed by radiotherapy and adjuvant chemotherapy, survival remains poor at a rate of 26.5% at 2 years. Recent… read more here.
Keywords: tumor; glioblastoma; resistance; immunotherapy resistance ... See more keywords
Mechanisms Governing Immunotherapy Resistance in Pancreatic Ductal Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.613815
Abstract: Pancreatic ductal adenocarcinoma (PDA) is a lethal malignancy with an overall 5-year survival rate of 10%. Disease lethality is due to late diagnosis, early metastasis and resistance to therapy, including immunotherapy. PDA creates a robust… read more here.
Keywords: immunotherapy resistance; resistance; pancreatic ductal; ductal adenocarcinoma ... See more keywords
Mechanism and strategies of immunotherapy resistance in colorectal cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1016646
Abstract: Colorectal cancer (CRC) is the third most common cancer in the world. Although there are standard treatment options for CRC, most patients respond poorly to these treatments. Immunotherapies have gradually emerged due to the increasing… read more here.
Keywords: immunotherapy resistance; strategies immunotherapy; colorectal cancer; resistance ... See more keywords
Immunotherapy resistance in esophageal cancer: Possible mechanisms and clinical implications
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.975986
Abstract: Esophageal cancer (EC) is a common malignant gastrointestinal (GI) cancer in adults. Although surgical technology combined with neoadjuvant chemoradiotherapy has advanced rapidly, patients with EC are often diagnosed at an advanced stage and the five-year… read more here.
Keywords: esophageal cancer; immunotherapy; immunotherapy resistance; resistance esophageal ... See more keywords
Identification of Key Pathways and Genes Related to Immunotherapy Resistance of LUAD Based on WGCNA Analysis
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.814014
Abstract: Immunotherapy resistance is a major barrier in the application of immune checkpoint inhibitors (ICI) in lung adenocarcinoma (LUAD) patients. Although recent studies have found several mechanisms and potential genes responsible for immunotherapy resistance, ways to… read more here.
Keywords: analysis; resistance; immunotherapy resistance; luad patients ... See more keywords
Mechanisms of Immunotherapy Resistance in Cutaneous Melanoma: Recognizing a Shapeshifter
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.880876
Abstract: Melanoma is one of the seven most common cancers in the United States, and its incidence is still increasing. Since 2011, developments in targeted therapies and immunotherapies have been essential for significantly improving overall survival… read more here.
Keywords: melanoma; immunotherapy resistance; resistance; mechanisms immunotherapy ... See more keywords
Nanoparticle-Based Drug Delivery Systems Targeting Tumor Microenvironment for Cancer Immunotherapy Resistance: Current Advances and Applications
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14101990
Abstract: Cancer immunotherapy has shown impressive anti-tumor activity in patients with advanced and early-stage malignant tumors, thus improving long-term survival. However, current cancer immunotherapy is limited by barriers such as low tumor specificity, poor response rate,… read more here.
Keywords: immunotherapy; immunotherapy resistance; tumor; cancer immunotherapy ... See more keywords