Cuproptosis-Mediated Patterns Characterized by Distinct Tumor Microenvironment and Predicted the Immunotherapy Response for Gastric Cancer
Sign Up to like & getrecommendations! Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.2c07052
Abstract: Cuproptosis is a newly discovered programmed cell death process, and several cuproptosis-related genes have been reported to regulate cancer cell proliferation and progression. The association between cuproptosis and tumor microenvironment in gastric cancer (GC) remains… read more here.
Keywords: immunotherapy response; cuproptosis; cancer; tumor microenvironment ... See more keywords
Tissue and peripheral T cell receptor repertoire predicts immunotherapy response and progression-free survival in NSCLC patients
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DOI: 10.1038/s41598-025-21612-3
Abstract: Immunotherapy has opened new avenues of treatment for patients with advanced non-small cell lung cancer (NSCLC) without previous hope of survival. Unfortunately, only a small percentage of patients benefit from it and there is not… read more here.
Keywords: nsclc patients; repertoire; response; immunotherapy response ... See more keywords
Construction of immune-related LncRNAs classifier to predict prognosis and immunotherapy response in thymic epithelial tumors
Sign Up to like & getrecommendations! Published in 2022 at "Bioscience Reports"
DOI: 10.1042/bsr20220317
Abstract: Abstract The primary objective of this study was to construct an immune-related long noncoding RNAs (IRLs) classifier to precisely predict the prognosis and immunotherapy response of patients with thymic epithelial tumors (TET). Based on univariable… read more here.
Keywords: immunotherapy; predict prognosis; immunotherapy response; irl classifier ... See more keywords
Role of radiomics in predicting immunotherapy response
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Imaging and Radiation Oncology"
DOI: 10.1111/1754-9485.13426
Abstract: Immunotherapies have revolutionised cancer management. Despite their success, durable responses are limited to a subset of patients. Prediction of immunotherapy response in patients has proven to be difficult due to a lack of robust biomarkers.… read more here.
Keywords: role radiomics; predicting immunotherapy; immunotherapy response; radiomics predicting ... See more keywords
Single‐Cell Transcriptomics Identifies Novel Prognostic Signatures in HNSCC Immunotherapy Response
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DOI: 10.1111/cas.70171
Abstract: Head and neck squamous cell carcinoma (HNSCC) poses a major therapeutic challenge. In this study, we aimed to analyze tumor immune microenvironment changes and develop a prognostic model based on immunotherapy response. We analyzed single‐cell… read more here.
Keywords: single cell; immunotherapy response; cell; hnscc immunotherapy ... See more keywords
Baseline prognostic nutritional index and changes in pretreatment body mass index associate with immunotherapy response in patients with advanced cancer
Sign Up to like & getrecommendations! Published in 2020 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2020-001674
Abstract: Background Recent research suggests that baseline body mass index (BMI) is associated with response to immunotherapy. In this study, we test the hypothesis that worsening nutritional status prior to the start of immunotherapy, rather than… read more here.
Keywords: index; response; immunotherapy response; baseline ... See more keywords
Mitochondrial Pathway Signature (MitoPS) predicts immunotherapy response and reveals NDUFB10 as a key immune regulator in lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2025 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2025-012069
Abstract: Background Lung adenocarcinoma (LUAD) is the most common subtype of non-small cell lung cancer. Although immune checkpoint inhibitors (ICIs) have brought new treatment options for advanced patients, a considerable proportion still shows limited response. Mitochondrial… read more here.
Keywords: lung adenocarcinoma; response; mitochondrial pathway; immunotherapy response ... See more keywords
Identification and Validation of a Novel Multiomics Signature for Prognosis and Immunotherapy Response of Endometrial Carcinoma
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DOI: 10.1155/2022/8998493
Abstract: Purpose Cancer development and immune escape involve DNA methylation, copy number variation, and other molecular events. However, there are remarkably few studies integrating multiomics genetic profiles into endometrial cancer (EC). This study aimed to develop… read more here.
Keywords: immunotherapy response; multiomics signature; signature; validation ... See more keywords
Abstract B24: Digital signatures of T cell dysfunction predict immunotherapy response
Sign Up to like & getrecommendations! Published in 2018 at "Cancer immunology research"
DOI: 10.1158/2326-6074.tumimm17-b24
Abstract: Despite success in treating several cancer types, immunotherapy only shows response in a subset of patients. Predicting immunotherapy response and understanding the resistance mechanisms are still open questions. We present a computational framework, Tumor Immune… read more here.
Keywords: cell dysfunction; immunotherapy response; response; immunology ... See more keywords
Single-cell RNA sequencing reveals neutrophil differentiation-related genes for immunotherapy response prediction in colorectal cancer.
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DOI: 10.1186/s12885-025-15355-7
Abstract: Immunotherapy has demonstrated promising results in treating colorectal cancer (CRC), yet not all patients benefit equally, highlighting the need for predictive biomarkers and additional adjuvant. Neutrophils, pivotal in immune regulation and inflammation, remain underexplored in… read more here.
Keywords: immunotherapy; cancer; neutrophil differentiation; immunotherapy response ... See more keywords
Spatial insights into immunotherapy response in non-small cell lung cancer (NSCLC) by multiplexed tissue imaging
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-024-05035-8
Abstract: The spatial localisation of immune cells within tumours are key to understand the intercellular communications that can dictate clinical outcomes. Here, we demonstrate an analysis pipeline for highly multiplexed CODEX data to phenotype and profile… read more here.
Keywords: cd8 cells; response; responding patients; immunotherapy response ... See more keywords