Systematic Immunotherapy Target Discovery Using Genome-Scale In Vivo CRISPR Screens in CD8 T Cells
Sign Up to like & getrecommendations! Published in 2019 at "Cell"
DOI: 10.1016/j.cell.2019.07.044
Abstract: CD8 T cells play essential roles in anti-tumor immune responses. Here, we performed genome-scale CRISPR screens in CD8 T cells directly under cancer immunotherapy settings and identified regulators of tumor infiltration and degranulation. The in vivo screen robustly re-identified… read more here.
Keywords: genome scale; immunotherapy; immunotherapy target; cd8 cells ... See more keywords
In vivo multidimensional CRISPR screens identify Lgals2 as an immunotherapy target in triple-negative breast cancer
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abl8247
Abstract: Immune checkpoint inhibitors exhibit limited response rates in patients with triple-negative breast cancer (TNBC), suggesting that additional immune escape mechanisms may exist. Here, we performed two-step customized in vivo CRISPR screens targeting disease-related immune genes… read more here.
Keywords: immunotherapy target; immunotherapy; crispr screens; triple negative ... See more keywords