Immunotoxicity in green mussels under perfluoroalkyl substance (PFAS) exposure: Reversible response and response model development.
Sign Up to like & getrecommendations! Published in 2018 at "Environmental toxicology and chemistry"
DOI: 10.1002/etc.4060
Abstract: The immunotoxicity of 4 commonly detected perfluoroalkyl substances (PFASs), namely, perfluorooctanesulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFDA) was investigated by measuring biomarkers of the immune profile of green mussels, Perna… read more here.
Keywords: pfass; response; pfas; exposure ... See more keywords
In vivo immunotoxicity of Gd2O3:Eu3+ nanoparticles and the associated molecular mechanism
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22562
Abstract: The in vivo toxicity of Gd2O3:Eu3+ nanoparticles (NPs) used as dual‐modal nanoprobes for molecular imaging has not been studied, and the corresponding molecular mechanism of immunotoxicity remains unknown. In this study, we investigated the cytotoxicity,… read more here.
Keywords: immunotoxicity; gd2o3 eu3; molecular mechanism; vivo ... See more keywords
The potential immunotoxicity of emamectin benzoate on the human THP‐1 macrophages
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23681
Abstract: Emamectin benzoate (EMB) as one of the typical biological pesticides has a wide range of applications in agriculture. However, the immune toxic effects of EMB in human received limited attention. In our study, THP‐1 macrophage… read more here.
Keywords: thp macrophages; immunotoxicity; emamectin benzoate; potential immunotoxicity ... See more keywords
Investigation on the immunotoxicity induced by Emamectin benzoate on THP‐1 macrophages based on metabolomics analysis
Sign Up to like & getrecommendations! Published in 2023 at "Environmental Toxicology"
DOI: 10.1002/tox.23747
Abstract: Emamectin benzoate (EMB) is an insecticide extensively used in agricultural area. Assessing the toxic effects of EMB in mammals or humans and its endogenous metabolites alteration are the appropriate means of evaluating its risks to… read more here.
Keywords: macrophages based; immunotoxicity; based metabolomics; analysis ... See more keywords
Arsenic (III) or/and copper (II) exposure induce immunotoxicity through trigger oxidative stress, inflammation and immune imbalance in the bursa of chicken.
Sign Up to like & getrecommendations! Published in 2019 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2019.110127
Abstract: The environmental hazards of arsenic (As) and copper (Cu) contamination have swept through quite a few districts worldwide. Whereas, molecular mechanisms involved in As- and Cu-induced immunotoxicity in Gallus gallus bursa of Fabricius (BF) are… read more here.
Keywords: imbalance; inflammation; copper; exposure ... See more keywords
Poly- and Perfluoroalkyl Substances Induce Immunotoxicity via the TLR Pathway in Zebrafish: Links to Carbon Chain Length.
Sign Up to like & getrecommendations! Published in 2023 at "Environmental science & technology"
DOI: 10.1021/acs.est.2c09716
Abstract: Previous studies have reported the immunotoxicity of per- and polyfluoroalkyl substances (PFASs), but it remains a significant challenge to assess over 10,000 distinct PFASs registered in the distributed structure-searchable toxicity (DSSTox) database. We aim to… read more here.
Keywords: carbon chain; chain length; carbon; immunotoxicity ... See more keywords
Weight of evidence evaluation for chemical-induced immunotoxicity for PFOA and PFOS: findings from an independent panel of experts
Sign Up to like & getrecommendations! Published in 2023 at "Critical Reviews in Toxicology"
DOI: 10.1080/10408444.2023.2194913
Abstract: Abstract Immunotoxicity is the critical endpoint used by some regulatory agencies to establish toxicity values for perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS). However, the hypothesis that exposure to certain per- and polyfluoroalkyl substances (PFAS)… read more here.
Keywords: panel; pfoa pfos; immunotoxicity; weight evidence ... See more keywords
Invited Perspective: Key Characteristics as a Starting Point for Improved Hazard Identification of Immunotoxic Agents
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Health Perspectives"
DOI: 10.1289/ehp11726
Abstract: In this issue, Germolec et al. identified “key characteristics” (KCs) for immunoactive substances and described how such characteristics could be applied to improve hazard assessment of potentially immunomodulatory agents. KCs, or the properties associated with… read more here.
Keywords: system; germolec; immunotoxicity; identification ... See more keywords
Humanized Mouse as a Tool to Predict Immunotoxicity of Human Biologics
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.553362
Abstract: Advancements in science enable researchers to constantly innovate and create novel biologics. However, the use of non-human animal models during the development of biologics impedes identification of precise in vivo interactions between the human immune… read more here.
Keywords: tool predict; humanized mice; immunotoxicity; predict immunotoxicity ... See more keywords
Assessing Fish Immunotoxicity by Means of In Vitro Assays: Are We There Yet?
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.835767
Abstract: There is growing awareness that a range of environmental chemicals target the immune system of fish and may compromise the resistance towards infectious pathogens. Existing concepts to assess chemical hazards to fish, however, do not… read more here.
Keywords: immune cells; immunotoxicity; vitro assays; fish immunotoxicity ... See more keywords
NLRP3 inflammasome as a sensor of micro- and nanoplastics immunotoxicity
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1178434
Abstract: Micro- and nanoplastics (MNPs) are emerging pollutants with scarcely investigated effects on human innate immunity. If they follow a similar course of action as other, more thoroughly investigated particulates, MNPs may penetrate epithelial barriers, potentially… read more here.
Keywords: immunotoxicity; inflammasome activation; micro nanoplastics; activation ... See more keywords