Expression of VGRNb-PE immunotoxin in transplastomic lettuce (Lactuca sativa L.)
Sign Up to like & getrecommendations! Published in 2018 at "Plant Molecular Biology"
DOI: 10.1007/s11103-018-0726-9
Abstract: Key messageThis research has shown, for the first time, that plant chloroplasts are a suitable compartment for synthesizing recombinant immunotoxins and the transgenic immunotoxin efficiently causes the inhibition of VEGFR2 overexpression, cell growth and proliferation.AbstractAngiogenesis… read more here.
Keywords: lettuce; expression; vgrnb immunotoxin; immunotoxin ... See more keywords
Treatment of Cytomegalovirus in Human Donor Lungs with a Novel Chemokine-Based Immunotoxin during Ex Vivo Lung Perfusion Prevents Viral Reactivation
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Heart and Lung Transplantation"
DOI: 10.1016/j.healun.2021.01.938
Abstract: Purpose Post-transplant CMV reactivation from latently-infected lung allografts is extremely prevalent and results in inferior long-term outcomes. CMV latently infected cells ubiquitously express a viral surface protein, US28. We aimed to evaluate the therapeutic effects… read more here.
Keywords: reactivation; lung; immunotoxin; chemokine ... See more keywords
Reduction of non‐specific toxicity of immunotoxin by intein mediated reconstitution on target cells
Sign Up to like & getrecommendations! Published in 2019 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2018.11.039
Abstract: &NA; Recombinant immunotoxins are chimeric proteins composed of a targeting peptide that binds to a specific tumor antigen and a toxin protein killing target cells. Recombinant immunotoxin exhibits potent cancer inhibiting effects both in vivo… read more here.
Keywords: specific toxicity; intein mediated; non specific; toxicity ... See more keywords
Deamidation in Moxetumomab Pasudotox Leading to Conformational Change and Immunotoxin Activity Loss.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2020.06.002
Abstract: Asparagine deamidation is a common posttranslational modification in which asparagine (Asn) is converted to aspartic acid or isoaspartic acid. By introducing a negative charge, deamidation could potentially impact the binding interface and biological activities of… read more here.
Keywords: deamidation; activity; moxetumomab pasudotox; immunotoxin ... See more keywords
Anti-tumoral potential of a human granulysin-based, CEA-targeted cytolytic immunotoxin
Sign Up to like & getrecommendations! Published in 2019 at "OncoImmunology"
DOI: 10.1080/2162402x.2019.1641392
Abstract: ABSTRACT Granulysin is a protein present in the granules of human cytotoxic T lymphocytes (CTL) and natural killer (NK) cells, with cytolytic activity against microbes and tumors. Previous work demonstrated the therapeutic effect of intratumoral… read more here.
Keywords: anti tumoral; cea; tumoral potential; immunotoxin ... See more keywords
Potent anti-tumor activity of CD45RA-targeting Hm3A4-Ranpirnase against myeloid lineage leukemias
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2054159
Abstract: ABSTRACT CD45RA is a specific marker for leukemia stem cell (LSC) sub-populations in acute myeloid leukemia (AML). Ranpirnase (Rap), an amphibian RNase, has been extensively investigated in preclinical and clinical studies for its antitumor activity.… read more here.
Keywords: immunotoxin; activity; potent anti; rap ... See more keywords
Production and Evaluation of an Avian IgY Immunotoxin against CD133+ for Treatment of Carcinogenic Stem Cells in Malignant Glioma: IgY Immunotoxin for the Treatment of Glioblastoma
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Oncology"
DOI: 10.1155/2019/2563092
Abstract: Background Glioblastoma is the most common malignant tumor of Central Nervous System. Despite the research in therapeutics, the prognosis is dismal. Malignant glioma stem cells (MGSCs) are a major cause of treatment failure and increasing… read more here.
Keywords: malignant glioma; cd133; treatment; igy ... See more keywords
GPC1-targeted immunotoxins inhibit pancreatic tumor growth in mice via depletion of short-lived GPC1 and downregulation of Wnt signaling.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular cancer therapeutics"
DOI: 10.1158/1535-7163.mct-21-0778
Abstract: Glypican-1 (GPC1) is a cell surface proteoglycan that is upregulated in multiple types of human cancers including pancreatic cancer. Here, we investigated whether GPC1 could be a target of antibody-toxin fusion proteins (i.e. immunotoxins) for… read more here.
Keywords: tumor growth; gpc1 targeted; immunotoxin; gpc1 ... See more keywords
Novel Treatment with Intraperitoneal MOC31PE Immunotoxin in Colorectal Peritoneal Metastasis: Results From the ImmunoPeCa Phase 1 Trial
Sign Up to like & getrecommendations! Published in 2017 at "Annals of Surgical Oncology"
DOI: 10.1245/s10434-017-5814-6
Abstract: BackgroundMOC31PE immunotoxin was developed to rapidly kill cells expressing the tumor-associated epithelial cell adhesion molecule, which is highly expressed in colorectal cancer. Although cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) may offer long-term survival… read more here.
Keywords: intraperitoneal; peritoneal metastasis; immunotoxin; dose ... See more keywords
HER2-specific recombinant immunotoxin 4D5scFv-PE40 passes through retrograde trafficking route and forces cells to enter apoptosis
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.15833
Abstract: Immunotoxin 4D5scFv-PE40 is a recombinant protein that comprises 4D5scFv antibody as a targeting module and fragment of Pseudomonas exotoxin A as an effector (toxic) one. The immunotoxin has shown pronounced antitumor effect on cancer cells… read more here.
Keywords: 4d5scfv pe40; immunotoxin 4d5scfv; immunotoxin; her2 ... See more keywords
Antibody-immunotoxin Conjugate Using FcBP-mediated Photoconjugation to Treat Cancer
Sign Up to like & getrecommendations! Published in 2022 at "AntiCancer Research"
DOI: 10.21873/anticanres.15832
Abstract: Background/Aim: Cytotoxic payload conjugation to antibodies efficiently suppresses tumors and contributes to the improvement of cancer survival. In our previous study, c-Kit targeting antibody–drug conjugate (2G4-DM1) with DM1, a microtubule inhibitor, efficiently suppressed tumor growth.… read more here.
Keywords: treat; immunotoxin; conjugate; 2g4 immunotoxin ... See more keywords