IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma
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DOI: 10.1038/s41556-019-0363-9
Abstract: In many cancers, high proliferation rates correlate with elevation of rRNA and tRNA levels, and nucleolar hypertrophy. However, the underlying mechanisms linking increased nucleolar transcription and tumorigenesis are only minimally understood. Here we show that… read more here.
Keywords: aberrant nucleolar; imp dehydrogenase; tumorigenesis; glioblastoma ... See more keywords