The Impact of APP on Alzheimer-like Pathogenesis and Gene Expression in Down Syndrome iPSC-Derived Neurons
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DOI: 10.1016/j.stemcr.2018.05.004
Abstract: Summary Early-onset Alzheimer disease (AD)-like pathology in Down syndrome is commonly attributed to an increased dosage of the amyloid precursor protein (APP) gene. To test this in an isogenic human model, we deleted the supernumerary… read more here.
Keywords: app gene; gene expression; pathogenesis; expression ... See more keywords