The Impact of the Cellular Environment and Aging on Modeling Alzheimer's Disease in 3D Cell Culture Models
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202205037
Abstract: Creating a cellular model of Alzheimer's disease (AD) that accurately recapitulates disease pathology has been a longstanding challenge. Recent studies showed that human AD neural cells, integrated into three‐dimensional (3D) hydrogel matrix, display key features… read more here.
Keywords: ecm; disease; alzheimer disease; cellular environment ... See more keywords
Modeling aging and its impact on cellular function and organismal behavior
Sign Up to like & getrecommendations! Published in 2021 at "Experimental Gerontology"
DOI: 10.1016/j.exger.2021.111577
Abstract: Aging is a complex phenomenon of functional decay in a biological organism. Although the effects of aging are readily recognizable in a wide range of organisms, the cause(s) of aging are ill defined and poorly… read more here.
Keywords: aging impact; modeling aging; biology; computational biology ... See more keywords
The impact of cellular metabolism on chromatin dynamics and epigenetics
Sign Up to like & getrecommendations! Published in 2017 at "Nature Cell Biology"
DOI: 10.1038/ncb3629
Abstract: The substrates used to modify nucleic acids and chromatin are affected by nutrient availability and the activity of metabolic pathways. Thus, cellular metabolism constitutes a fundamental component of chromatin status and thereby of genome regulation.… read more here.
Keywords: chromatin; cellular metabolism; biology; impact cellular ... See more keywords