The impact of the CYP2D6 "enhancer" single nucleotide polymorphism on CYP2D6 activity.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical pharmacology and therapeutics"
DOI: 10.1002/cpt.2469
Abstract: rs5758550 has been associated with enhanced transcription and suggested to be a useful marker of CYP2D6 activity. As there are limited and inconsistent data regarding the utility of this distant "enhancer" single nucleotide polymorphism (SNP),… read more here.
Keywords: cyp2d6; enhancer snp; cyp2d6 activity; impact cyp2d6 ... See more keywords
Impact of CYP2D6 Genotype on Paroxetine Serum Concentration.
Sign Up to like & getrecommendations! Published in 2023 at "Therapeutic drug monitoring"
DOI: 10.1097/ftd.0000000000001096
Abstract: BACKGROUND Paroxetine is a selective serotonin reuptake inhibitor metabolized by cytochrome P450 (CYP)2D6. Only small-scale studies have reported the impact of CYP2D6 genotype on paroxetine exposure, and international guidelines differ in their recommendations on whether… read more here.
Keywords: paroxetine; cyp2d6; impact cyp2d6; cyp2d6 genotype ... See more keywords
The impact of CYP2D6*41 on CYP2D6 enzyme activity using phenotyping methods in urine, plasma, and saliva
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.940510
Abstract: Aims: The CYP2D6*41 variant is the second or third frequent reduced function allele in Chinese with a frequency of around 3–4%, while it is the major reduced function allele in Indians, Saudi Arabians and Caucasians… read more here.
Keywords: cyp2d6 cyp2d6; cyp2d6; impact cyp2d6; plasma ... See more keywords