Stimuli-sensitive crosslinked hydrogels as drug delivery systems: Impact of the drug on the responsiveness.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2020.119157
Abstract: Responsiveness of drug delivery systems (DDS) against internal and external stimuli attracts wide interest as a mechanism that can provide both site-specific release at the target place and feedback regulated release rate. Biological environment is… read more here.
Keywords: drug responsiveness; impact drug; drug delivery; delivery systems ... See more keywords
Impact of Drug Conjugation on Thermal and Metabolic Stabilities of Aglycosylated and N-Glycosylated Antibodies
Sign Up to like & getrecommendations! Published in 2022 at "Bioconjugate Chemistry"
DOI: 10.1021/acs.bioconjchem.1c00572
Abstract: N-linked glycosylation is one of the most common and complex posttranslational modifications that govern the biological functions and physicochemical properties of therapeutic antibodies. We evaluated thermal and metabolic stabilities of antibody–drug conjugates (ADCs) with payloads… read more here.
Keywords: drug conjugation; impact drug; conjugation; thermal metabolic ... See more keywords
Enteric reabsorption processes and their impact on drug pharmacokinetics
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DOI: 10.1038/s41598-021-85174-w
Abstract: Enteric reabsorption occurs when a drug is secreted into the intestinal lumen and reabsorbed into the systemic circulation. This distribution process is evidenced by multiple peaks in pharmacokinetic profiles. Commonly, hepatobiliary drug secretion is assumed… read more here.
Keywords: enteric reabsorption; impact drug; reabsorption; drug ... See more keywords
The impact of drug interactions on adverse effects of oral oxycodone in male geriatric patients
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Pharmacy and Therapeutics"
DOI: 10.1111/jcpt.13113
Abstract: With increased opioid use, drug‐drug interactions (DDIs) and associated adverse events are growing among geriatric patients. However, the clinical significance of potential metabolic DDIs associated with opioid use has not been fully evaluated among geriatric… read more here.
Keywords: impact drug; drug interactions; interactions adverse; drug ... See more keywords
Long term outcomes of patients with tuberculous meningitis: The impact of drug resistance
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DOI: 10.1371/journal.pone.0270201
Abstract: Background Little is known about the impact of drug-resistance on clinical outcomes among patients with tuberculosis meningitis (TBM). Methods A retrospective cohort study among patients treated for TBM in Tbilisi, Georgia. We performed medical chart… read more here.
Keywords: long term; impact drug; resistance; among patients ... See more keywords