Intron retention and its impact on gene expression and protein diversity: A review and a practical guide
Sign Up to like & getrecommendations! Published in 2020 at "Wiley Interdisciplinary Reviews: RNA"
DOI: 10.1002/wrna.1631
Abstract: Intron retention (IR) occurs when a complete and unspliced intron remains in mature mRNA. An increasing body of literature has demonstrated a major role for IR in numerous biological functions, including several that impact human… read more here.
Keywords: gene expression; impact gene; intron retention; expression protein ... See more keywords
First prospective multicenter Italian study on the impact of the 21-Gene Recurrence Score (RS) in adjuvant clinical decisions for ER+/HER2- early breast cancer (BC) patients.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.e12038
Abstract: e12038Background: The Breast-DX Italy prospective study evaluated the impact of the 21-gene RS on adjuvant treatment decisions for early BC patients. Methods: The study was conducted in 9 centers of the Veneto Region (2 hub… read more here.
Keywords: breast; first prospective; study; her2 early ... See more keywords
Impact of a gene expression profiling risk score and web-based melanoma outcome calculator on the precision of AJCC-based prognostic assessment.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.9582
Abstract: 9582Background: AJCC staging of primary cutaneous melanoma (CM), based on clinico-pathological criteria, is limited in its ability to provide a precise prognosis for all patients. To improve risk a... read more here.
Keywords: profiling risk; risk; risk score; gene expression ... See more keywords
Intragenic CpG Islands and Their Impact on Gene Regulation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.832348
Abstract: The mammalian genome is depleted in CG dinucleotides, except at protected regions where they cluster as CpG islands (CGIs). CGIs are gene regulatory hubs and serve as transcription initiation sites and are as expected, associated… read more here.
Keywords: cpg islands; intragenic cpg; islands impact; gene ... See more keywords