Impact of IgG subclass on molecular properties of monoclonal antibodies.
Sign Up to like & getrecommendations! Published in 2021 at "mAbs"
DOI: 10.1080/19420862.2021.1993768
Abstract: Immunoglobulin G-based monoclonal antibodies (mAbs) have become a dominant class of biotherapeutics in recent decades. Approved antibodies are mainly of the subclasses IgG1, IgG2, and IgG4, as well as their derivatives. Over the decades, the… read more here.
Keywords: igg subclass; impact igg; monoclonal antibodies; molecular properties ... See more keywords
Impact of IgG subclass on monoclonal antibody developability
Sign Up to like & getrecommendations! Published in 2023 at "mAbs"
DOI: 10.1080/19420862.2023.2191302
Abstract: ABSTRACT IgG-based monoclonal antibody therapeutics, which are mainly IgG1, IgG2, and IgG4 subclasses or related variants, have dominated the biotherapeutics field for decades. Multiple laboratories have reported that the IgG subclasses possess different molecular characteristics… read more here.
Keywords: impact igg; igg subclass; monoclonal antibody; subclass ... See more keywords