Impact of Fc N-linked glycans on in vivo clearance of an immunoglobulin G1 antibody produced by NS0 cell line
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DOI: 10.1080/19420862.2020.1844928
Abstract: ABSTRACT The heterogeneity of glycosylation on therapeutic monoclonal antibodies (mAbs) may affect the safety and efficacy of these agents. In particular, glycans of nonhuman origin, such as galactose-alpha-1,3-galactose (gal-α-gal) and N-glycolylneuraminic acid (NGNA), in the… read more here.
Keywords: glycans vivo; impact linked; antibody; vivo clearance ... See more keywords
Impact of X-Linked Hypophosphatemia on Muscle Symptoms
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DOI: 10.3390/genes13122415
Abstract: X-linked hypophosphatemia (XLH) is the most common hereditary form of rickets and deficiency of renal tubular phosphate transport in humans. XLH is caused by the inactivation of mutations within the phosphate-regulating endopeptidase homolog X-linked (PHEX)… read more here.
Keywords: phosphate; muscle; impact linked; hypophosphatemia muscle ... See more keywords