Prognostic and predictive impact of MGMT promoter methylation in grade 3 gliomas
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Neuroscience"
DOI: 10.1016/j.jocn.2020.12.028
Abstract: BACKGROUND Grade 3 gliomas are aggressive primary brain tumors. Promoter methylation of methyl guanine methyl transferase (MGMT) has been associated with a favorable prognosis in patients with glioblastoma, but the impact of MGMT promoter methylation… read more here.
Keywords: methylation; grade glioma; mgmt; promoter methylation ... See more keywords
Impact of predictive impact of MGMT promoter methylation in malignant astrocytomas depends on the methylation subgroup.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.2013
Abstract: 2013 Background: O6-methylguanine DNA-methyl transferase (MGMT) status is predictive for alkylating chemotherapy in most series, but there are non-benefitting subgroups. Despite multiple attempts, MGMT has not been unambiguously established as a predictive biomarker for patients… read more here.
Keywords: mgmt; mgmt promoter; methylation; impact mgmt ... See more keywords