Impact of Mutational Profile on the Management of Myeloproliferative Neoplasms: A Short Review of the Emerging Data
Sign Up to like & getrecommendations! Published in 2020 at "OncoTargets and therapy"
DOI: 10.2147/ott.s287944
Abstract: Abstract Philadelphia-chromosome negative myeloproliferative neoplasms (MPN) are a heterogeneous group of clonal hematopoietic stem cell disorders characterized by an increased risk of thrombosis and progression to acute myeloid leukemia. MPN are associated with driver mutations… read more here.
Keywords: myeloproliferative neoplasms; review; mutational profile; profile management ... See more keywords
Enhanced ER proteostasis and temperature differentially impact the mutational tolerance of influenza hemagglutinin
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DOI: 10.7554/elife.38795
Abstract: We systematically and quantitatively evaluate whether endoplasmic reticulum (ER) proteostasis factors impact the mutational tolerance of secretory pathway proteins. We focus on influenza hemaggluttinin (HA), a viral membrane protein that folds in the host’s ER… read more here.
Keywords: temperature; tolerance; proteostasis; influenza ... See more keywords