Impact of mutations in hVISA isolates on decreased susceptibility to vancomycin, through population analyses profile - area under curve (PAP-AUC).
Sign Up to like & getrecommendations! Published in 2019 at "Diagnostic microbiology and infectious disease"
DOI: 10.1016/j.diagmicrobio.2019.06.006
Abstract: We analyzed sequences of graSR, vraSR, walKR and rpoB genes in hVISA from Brazil. Five isolates showed mutations in at least one gene. rpoB H481N and graS T224I were the most frequent mutations, followed by… read more here.
Keywords: mutations hvisa; decreased susceptibility; isolates decreased; susceptibility vancomycin ... See more keywords
Impact of Mutations on NPAC Structural Dynamics: Mechanistic Insights from MD Simulations
Sign Up to like & getrecommendations! Published in 2019 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.9b00588
Abstract: NPAC is a cytokine-like nuclear factor involved in chromatin modification and regulation of gene expression. In humans, the C-terminal domain of NPAC has the conserved structure of the β-hydroxyacid dehydrogenases (β-HAD) protein superfamily, which forms… read more here.
Keywords: structural dynamics; mutations npac; npac structural; dynamics mechanistic ... See more keywords
DynaMut: predicting the impact of mutations on protein conformation, flexibility and stability
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky300
Abstract: Abstract Proteins are highly dynamic molecules, whose function is intrinsically linked to their molecular motions. Despite the pivotal role of protein dynamics, their computational simulation cost has led to most structure-based approaches for assessing the… read more here.
Keywords: mutations protein; flexibility; stability; impact mutations ... See more keywords
The Impact of Mutations in Wolframin on Psychiatric Disorders
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pediatrics"
DOI: 10.3389/fped.2021.718132
Abstract: Wolfram Syndrome is a rare autosomal recessive disease characterized by early-onset diabetes mellitus, neurodegeneration, and psychological disorders. Mutations in the gene WFS1, coding for the protein wolframin, cause Wolfram Syndrome and are associated with bipolar… read more here.
Keywords: wfs1 mutations; psychiatric disorders; wolfram syndrome; mutations wolframin ... See more keywords