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Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkad268
Abstract: Abstract Herein, we report the systematic investigation of stereopure phosphorothioate (PS) and phosphoryl guanidine (PN) linkages on siRNA-mediated silencing. The incorporation of appropriately positioned and configured stereopure PS and PN linkages to N-acetylgalactosamine (GalNAc)-conjugated siRNAs…
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Keywords:
potency durability;
stereopure;
impact stereopure;
rna interference ... See more keywords