Human iPSC-derived RPE and retinal organoids reveal impaired alternative splicing of genes involved in pre-mRNA splicing in PRPF31 autosomal dominant retinitis pigmentosa
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DOI: 10.2139/ssrn.3155753
Abstract: Mutations in pre-mRNA processing factors (PRPFs) cause 40% of autosomal dominant retinitis pigmentosa (RP), but it is unclear why mutations in ubiquitously expressed PRPFs cause retinal disease. To understand the molecular basis of this phenotype,… read more here.
Keywords: retinitis pigmentosa; autosomal dominant; impaired alternative; dominant retinitis ... See more keywords