IMPAIRED AUTOPHAGIC FLUX CONTRIBUTES TO THE ACCUMULATION OF UBIQUITINATED PROTEINS IN A MOUSE MODEL OF HEART FAILURE
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American College of Cardiology"
DOI: 10.1016/s0735-1097(17)34261-4
Abstract: Background: In the failing heart there is impaired protein turnover and an accumulation of ubiquitinated proteins within cardiomyocytes. This accumulation, which likely has detrimental effects on myocyte function, has been attributed to proteasome dysfunction. However,… read more here.
Keywords: heart; ubiquitinated proteins; accumulation ubiquitinated; autophagic flux ... See more keywords
Impaired Autophagic Activity Contributes to the Pathogenesis of Bronchopulmonary Dysplasia: Evidence from Murine and Baboon Models.
Sign Up to like & getrecommendations! Published in 2020 at "American journal of respiratory cell and molecular biology"
DOI: 10.1165/rcmb.2019-0445oc
Abstract: RATIONALE The incidence of bronchopulmonary dysplasia (BPD) has been increasing due to improved survival of extremely low birth weight infants. The pathogenesis of BPD is incompletely understood and there is a shortage of effective treatments.… read more here.
Keywords: bronchopulmonary dysplasia; baboon; impaired autophagic; mice ... See more keywords
Endoplasmic Reticulum Stress Contributed to Dipyridamole-Induced Impaired Autophagic Flux and Glioma Apoptosis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23020579
Abstract: Elevation of intracellular cAMP levels has been implicated in glioma cell proliferation inhibition, differentiation, and apoptosis. Inhibition of phosphodiesterase is a way to elevate intracellular cAMP levels. The present study aimed to investigate the anti-glioma… read more here.
Keywords: stress; apoptosis; impaired autophagic; autophagic flux ... See more keywords