Huntingtin Aggregation Impairs Autophagy, Leading to Argonaute-2 Accumulation and Global MicroRNA Dysregulation.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.07.017
Abstract: Many neurodegenerative diseases are characterized by the presence of intracellular protein aggregates, resulting in alterations in autophagy. However, the consequences of impaired autophagy for neuronal function remain poorly understood. In this study, we used cell… read more here.
Keywords: impairs autophagy; aggregation; accumulation; aggregation impairs ... See more keywords
Overweight in elderly people induces impaired autophagy in skeletal muscle
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.05.018
Abstract: Abstract Sarcopenia is the gradual loss of skeletal muscle mass, strength and quality associated with aging. Changes in body composition, especially in skeletal muscle and fat mass are crucial steps in the development of chronic… read more here.
Keywords: skeletal muscle; muscle overweight; muscle; impaired autophagy ... See more keywords
SPRED2 deficiency elicits cardiac arrhythmias and premature death via impaired autophagy.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2019.01.023
Abstract: Cardiac functionality is dependent on a balanced protein turnover. Accordingly, regulated protein decay is critical to maintain cardiac function. Here we demonstrate that deficiency of SPRED2, an intracellular repressor of ERK-MAPK signaling markedly expressed in… read more here.
Keywords: spred2 deficiency; spred2; impaired autophagy; deficiency elicits ... See more keywords
Impaired autophagy promotes hair loss in the C3H/HeJ mouse model of alopecia areata
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DOI: 10.1080/15548627.2022.2074104
Abstract: ABSTRACT Alopecia areata (AA) involves an aberrant immune attack on the hair follicle (HF), which leads to hair loss. Previous genetic data from our lab pointed to a connection between macroautophagy/autophagy and AA pathogenesis, and… read more here.
Keywords: hej mouse; c3h hej; impaired autophagy; hair loss ... See more keywords
APOE4 expression is associated with impaired autophagy and mitophagy in astrocytes
Sign Up to like & getrecommendations! Published in 2022 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.322452
Abstract: Among the risk factors for late onset sporadic Alzheimer’s disease (AD) is the expression of ε4 allele of apolipoprotein E (APOE4) gene (Mahley et al., 2006). Elevated amyloid processing and reduced degradation of Aβ, which… read more here.
Keywords: expression associated; mahley 2006; associated impaired; expression ... See more keywords
Impaired autophagy in amyloid-beta pathology: A traditional review of recent Alzheimer's research
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomedical Research"
DOI: 10.7555/jbr.36.20220145
Abstract: Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder. The major pathological changes in AD progression are the generation and accumulation of amyloid-beta (Aβ) peptides as well as the presence of abnormally hyperphosphorylated tau proteins… read more here.
Keywords: pathology; impaired autophagy; amyloid beta; research impaired ... See more keywords