The association between metabolite profiles and impaired bone microstructure in adult growth hormone deficient rats
Sign Up to like & getrecommendations! Published in 2024 at "BMC Musculoskeletal Disorders"
DOI: 10.1186/s12891-024-08010-y
Abstract: Adult growth hormone deficiency (AGHD) is associated with an increased risk of fractures and impaired bone microstructure. Understanding the metabolic changes accompanying bone deterioration in AGHD might provide insights into mechanisms behind molecular changes and… read more here.
Keywords: adult; growth hormone; bone microstructure; impaired bone ... See more keywords
Tanshinol Alleviates Microcirculation Disturbance and Impaired Bone Formation by Attenuating TXNIP Signaling in GIO Rats
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.722175
Abstract: Impaired bone formation is the main characteristics of glucocorticoid (GC)-induced osteoporosis (GIO), which can be ameliorated by tanshinol, an aqueous polyphenol isolated from Salvia miltiorrhiza Bunge. However, the underlying mechanism is still not entirely clear.… read more here.
Keywords: impaired bone; txnip signaling; gio rats; bone ... See more keywords
Alzheimer’s Disease and Impaired Bone Microarchitecture, Regeneration and Potential Genetic Links
Sign Up to like & getrecommendations! Published in 2023 at "Life"
DOI: 10.3390/life13020373
Abstract: Alzheimer’s Disease (AD) and osteoporosis are both age-related degenerative diseases. Many studies indicate that these two diseases share common pathogenesis mechanisms. In this review, the osteoporotic phenotype of AD mouse models was discussed, and shared… read more here.
Keywords: microarchitecture regeneration; impaired bone; disease; alzheimer disease ... See more keywords