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Impaired EIF2S3 function associated with a novel phenotype of X-linked hypopituitarism with glucose dysregulation

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0 Published in 2019 at "EBioMedicine"

DOI: 10.1016/j.ebiom.2019.03.013

Abstract: Background The heterotrimeric GTP-binding protein eIF2 forms a ternary complex with initiator methionyl-tRNA and recruits it to the 40S ribosomal subunit for start codon selection and thereby initiates protein synthesis. Mutations in EIF2S3, encoding the… read more here.

Keywords: glucose dysregulation; impaired eif2s3; hypopituitarism; novel phenotype ... See more keywords