Impaired IFNγ-Signaling and Mycobacterial Clearance in IFNγR1-Deficient Human iPSC-Derived Macrophages
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DOI: 10.1016/j.stemcr.2017.11.011
Abstract: Summary Mendelian susceptibility to mycobacterial disease (MSMD) is caused by inborn errors of interferon gamma (IFNγ) immunity and is characterized by severe infections by weakly virulent mycobacteria. Although IFNγ is the macrophage-activating factor, macrophages from… read more here.
Keywords: signaling mycobacterial; mycobacterial clearance; impaired ifn; ifn ... See more keywords