Blocking Ca2+ Channel β3 Subunit Reverses Diabetes
Sign Up to like & getrecommendations! Published in 2018 at "Cell Reports"
DOI: 10.1016/j.celrep.2018.06.086
Abstract: Summary Voltage-gated Ca2+ channels (Cav) are essential for pancreatic beta cell function as they mediate Ca2+ influx, which leads to insulin exocytosis. The β3 subunit of Cav (Cavβ3) has been suggested to regulate cytosolic Ca2+… read more here.
Keywords: insulin secretion; impaired insulin; ca2; subunit ... See more keywords
Impaired insulin signaling upon loss of ovarian function is associated with a reduction of tristetraprolin and an increased stabilization of chemokine in adipose tissue
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2017.09.002
Abstract: Loss of ovarian function can activate inflammation and lead to insulin resistance (IR). IR is also a core feature of obesity and obesity-associated metabolic dysfunction. Tristetraprolin/zinc finger protein 36 (TTP) interferes with TNF-α production by… read more here.
Keywords: insulin; ovarian function; ttp; impaired insulin ... See more keywords
Leaner Women with Impaired Insulin Secretion Accounts for about 40% of Gestational Diabetes Mellitus in Japan
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pregnancy"
DOI: 10.1155/2019/7578403
Abstract: Aim To identify the involvement of leanness and impaired insulin secretion with Japanese gestational diabetes mellitus (GDM). Method A cross-sectional study was conducted comprising 219 at-risk pregnant women who underwent a 75g glucose tolerance test… read more here.
Keywords: gestational diabetes; insulin; insulin secretion; group ... See more keywords