Functionally impaired isoforms regulate TMPRSS6 proteolytic activity
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DOI: 10.1371/journal.pone.0273825
Abstract: TMPRSS6 is a type II transmembrane serine protease involved in iron homeostasis expressed as 4 isoforms in humans. TMPRSS6 isoform 2 downregulates hepcidin production by cleaving hemojuvelin and other surface proteins of hepatocytes. The functions… read more here.
Keywords: tmprss6 isoforms; impaired isoforms; proteolytic activity; functionally impaired ... See more keywords