Myocardial inflammation is associated with impaired mitochondrial oxidative capacity in ischaemic cardiomyopathy
Sign Up to like & getrecommendations! Published in 2024 at "ESC Heart Failure"
DOI: 10.1002/ehf2.15133
Abstract: Myocardial inflammation and impaired mitochondrial oxidative capacity are hallmarks of heart failure (HF) pathophysiology. The extent of myocardial inflammation in patients suffering from ischaemic cardiomyopathy (ICM) or dilated cardiomyopathy (DCM) and its association with mitochondrial… read more here.
Keywords: ischaemic cardiomyopathy; myocardial inflammation; oxidative capacity; inflammation ... See more keywords
Neurodegenerative disorders, metabolic icebergs, and mitohormesis
Sign Up to like & getrecommendations! Published in 2024 at "Translational Neurodegeneration"
DOI: 10.1186/s40035-024-00435-8
Abstract: Neurodegenerative disorders are typically “split” based on their hallmark clinical, anatomical, and pathological features, but they can also be “lumped” by a shared feature of impaired mitochondrial biology. This leads us to present a scientific… read more here.
Keywords: mitohormesis; metabolic icebergs; biology; neurodegenerative disorders ... See more keywords
The Role of Impaired Mitochondrial Dynamics in MFN2-Mediated Pathology
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.858286
Abstract: The Mitofusin 2 protein (MFN2), encoded by the MFN2 gene, was first described for its role in mediating mitochondrial fusion. However, MFN2 is now recognized to play additional roles in mitochondrial autophagy (mitophagy), mitochondrial motility,… read more here.
Keywords: role; role impaired; impaired mitochondrial; pathology ... See more keywords
Impacts of impaired mitochondrial dynamics in hearing loss: Potential therapeutic targets
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.998507
Abstract: Mitochondria are the powerhouse of the cells. Under physiological conditions, mitochondrial fission and fusion maintain a dynamic equilibrium in the cytoplasm, which is referred to as mitochondrial dynamics. As an important approach to regulating mitochondrial… read more here.
Keywords: impacts impaired; hearing loss; loss; impaired mitochondrial ... See more keywords
Genetic Neuropathy Due to Impairments in Mitochondrial Dynamics
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DOI: 10.3390/biology10040268
Abstract: Simple Summary Mitochondria are organelles within our cells that are best known for their role in energy production. They are also able to fuse, divide, and move within the cell (referred to as mitochondrial dynamics).… read more here.
Keywords: genetic neuropathy; peripheral neuropathy; impaired mitochondrial; impairments mitochondrial ... See more keywords