Genetic Deficiency of MicroRNA-15a/16-1 Confers Resistance to Neuropathological Damage and Cognitive Dysfunction in Experimental Vascular Cognitive Impairment and Dementia.
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DOI: 10.1002/advs.202104986
Abstract: Chronic cerebral hypoperfusion-derived brain damage contributes to the progression of vascular cognitive impairment and dementia (VCID). Cumulative evidence has shown that microRNAs (miRs) are emerging as novel therapeutic targets for CNS disorders. In this study,… read more here.
Keywords: impairment dementia; vcid; damage; vascular cognitive ... See more keywords
The association between cognitive impairment/dementia and albuminuria: a systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2021 at "Clinical and Experimental Nephrology"
DOI: 10.1007/s10157-021-02127-3
Abstract: To identify the association between albuminuria and dementia or cognitive impairment. The literature search was performed to identify relevant scientific studies through August 2019, including PubMed/Medline and EMBASE. For inclusion, the studies had to fulfil… read more here.
Keywords: dementia; association; cognitive impairment; meta ... See more keywords
Genetic knockout of myosin light chain kinase (MLCK210) prevents cerebral microhemorrhages and attenuates neuroinflammation in a mouse model of vascular cognitive impairment and dementia
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DOI: 10.1007/s11357-019-00072-4
Abstract: The blood-brain barrier (BBB) is critical in maintenance of brain homeostasis, and loss of its functional integrity is a key feature across a broad range of neurological insults. This includes both acute injuries such as… read more here.
Keywords: myosin light; neuroinflammation; vascular cognitive; cognitive impairment ... See more keywords
Vascular Cognitive Impairment and Dementia: JACC Scientific Expert Panel.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2019.04.034
Abstract: Cognitive impairment associated with aging has emerged as one of the major public health challenges of our time. Although Alzheimer's disease is the leading cause of clinically diagnosed dementia in Western countries, cognitive impairment of… read more here.
Keywords: vascular cognitive; cognitive impairment; impairment; impairment dementia ... See more keywords
Arterial stiffness, cognitive impairment and dementia: confounding factor or real risk?
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DOI: 10.1111/jnc.14235
Abstract: Large artery stiffness is a frequent condition that arises with ageing, and is accelerated by the presence of co‐morbidities like hypertension, obesity and diabetes. Although epidemiological studies have indicated an association between arterial stiffness, cognitive… read more here.
Keywords: stiffness; stiffness cognitive; cognitive impairment; arterial stiffness ... See more keywords
Key elements of interventions for heart failure patients with mild cognitive impairment or dementia: A systematic review
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Cardiovascular Nursing"
DOI: 10.1177/1474515119865755
Abstract: Background: The purpose of this systematic review was to (a) examine the effects of interventions delivered by a heart failure professional for mild cognitive impairment and dementia on cognitive function, memory, working memory, instrumental activities… read more here.
Keywords: heart; heart failure; cognitive impairment; impairment dementia ... See more keywords
Hypoglycemia and the risk of cognitive impairment and dementia in elderly and senile patients with type 2 diabetes
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes mellitus"
DOI: 10.14341/dm10202
Abstract: Research results show that poor glycemic control and recurrent episodes of severe hypoglycaemia are associated with a decrease in cognitive function in elderly people with type 2 diabetes mellitus (T2DM). On the other hand, patients… read more here.
Keywords: risk; cognitive impairment; impairment; type diabetes ... See more keywords
Arterial Spin-Labeling Parameters and Their Associations with Risk Factors, Cerebral Small-Vessel Disease, and Etiologic Subtypes of Cognitive Impairment and Dementia
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DOI: 10.3174/ajnr.a7630
Abstract: BACKGROUND AND PURPOSE: Cerebral small-vessel disease may alter cerebral blood flow (CBF) leading to brain changes and, hence, cognitive impairment and dementia. CBF and the spatial coefficient of variation can be measured quantitatively by arterial… read more here.
Keywords: disease; cognitive impairment; spatial coefficient; coefficient variation ... See more keywords
Importance of Balance-Gait Disorder as a Risk Factor for Cognitive Impairment, Dementia and Related Non-Motor Symptoms in Parkinson's Disease.
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DOI: 10.3233/jpd-181375
Abstract: BACKGROUND In Parkinson's disease (PD), postural instability-gait disorder (PIGD) has been associated with more rapid cognitive decline, dementia, and greater non-motor symptom (NMS) burden. OBJECTIVE To assess the importance of balance-gait disorder, relative to and… read more here.
Keywords: dementia; balance gait; cognitive impairment; gait ... See more keywords
MicroRNA-Based Diagnosis and Therapeutics for Vascular Cognitive Impairment and Dementia
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DOI: 10.3389/fneur.2022.895316
Abstract: Vascular cognitive impairment and dementia (VCID) is a neurodegenerative disease that is recognized as the second leading cause of dementia after Alzheimer's disease (AD). The underlying pathological mechanism of VCID include crebromicrovascular dysfunction, blood-brain barrier… read more here.
Keywords: microrna based; vascular cognitive; cognitive impairment; impairment dementia ... See more keywords
Catastrophe Theory Applied to Neuropsychological Data: Nonlinear Effects of Depression on Financial Capacity in Amnestic Mild Cognitive Impairment and Dementia
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DOI: 10.3390/e24081089
Abstract: Financial incapacity is one of the cognitive deficits observed in amnestic mild cognitive impairment and dementia, while the combined interference of depression remains unexplored. The objective of this research is to investigate and propose a… read more here.
Keywords: capacity; mild cognitive; depression; amnestic mild ... See more keywords