Expression of Concern: Selective impairment of insulin signalling in the hypothalamus of obese Zucker rats
Sign Up to like & getrecommendations! Published in 2017 at "Diabetologia"
DOI: 10.1007/s00125-017-4358-4
Abstract: In line with guidelines issued by the Committee on Publication Ethics (COPE), the journal informed the corresponding author, Mario Saad, of this concern. Dr Saad has confirmed that different membranes could indeed have been used… read more here.
Keywords: concern selective; insulin signalling; selective impairment; expression concern ... See more keywords
Partial impairment of insulin receptor expression mimics fasting to prevent diet-induced fatty liver disease
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DOI: 10.1038/s41467-020-15623-z
Abstract: Excessive insulin signaling through the insulin receptor (IR) may play a role in the pathogenesis of diet-induced metabolic disease, including obesity and type 2 diabetes. Here we investigate whether heterozygous impairment of insulin receptor (IR)… read more here.
Keywords: insulin; receptor expression; diet induced; insulin receptor ... See more keywords
Impairment of insulin signalling in peripheral tissue fails to extend murine lifespan
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DOI: 10.1111/acel.12610
Abstract: Impaired insulin/IGF1 signalling has been shown to extend lifespan in model organisms ranging from yeast to mammals. Here we sought to determine the effect of targeted disruption of the insulin receptor (IR) in non‐neuronal tissues… read more here.
Keywords: insulin signalling; insulin; peripheral tissue; lifespan ... See more keywords