Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in Obesity.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.09.034
Abstract: Mitochondrial oxidative phosphorylation (OXPHOS) and substrate utilization critically regulate the function of hypothalamic proopiomelanocortin (POMC)-expressing neurons. Here, we demonstrate that inactivation of apoptosis-inducing factor (AIF) in POMC neurons mildly impairs mitochondrial respiration and decreases firing… read more here.
Keywords: pomc neurons; fatty acid; pomc; obesity ... See more keywords
Impairment of mitochondrial oxidative phosphorylation in skin fibroblasts of SALS and FALS patients is rescued by in vitro treatment with ROS scavengers
Sign Up to like & getrecommendations! Published in 2021 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2021.113620
Abstract: Amyotrophic lateral sclerosis (ALS) is a devastating, rapidly progressive, neurodegenerative disorder affecting upper and lower motor neurons. Approximately 10% of patients suffer from familial ALS (FALS) with mutations in different ubiquitously expressed genes including SOD1,… read more here.
Keywords: impairment mitochondrial; sals fals; mitochondrial oxidative; oxidative phosphorylation ... See more keywords
Impairment of mitochondrial function by particulate matter: Implications for the brain
Sign Up to like & getrecommendations! Published in 2020 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2020.104694
Abstract: Research efforts in the past decades have provided insight into the adverse health effects of air pollution exposure. Exposure to airborne particulate matter is known to impair the respiratory and cardiovascular systems, and more recent… read more here.
Keywords: matter; mitochondrial function; function particulate; particulate matter ... See more keywords
Vitamin C versus Cancer: Ascorbic Acid Radical and Impairment of Mitochondrial Respiration?
Sign Up to like & getrecommendations! Published in 2020 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2020/1504048
Abstract: Vitamin C as a cancer therapy has a controversial history. Much of the controversy arises from the lack of predictive biomarkers for stratification of patients, as well as a clear understanding of the mechanism of… read more here.
Keywords: mitochondrial respiration; vitamin versus; cancer; vitamin ... See more keywords
Impairment of Mitochondrial Respiration in Metabolic Diseases: An Overview
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23168852
Abstract: Mitochondrial dysfunction has emerged as a central pathomechanism in the setting of obesity and diabetes mellitus, linking these intertwined pathologies that share insulin resistance as a common denominator. High-resolution respirometry (HRR) is a state-of-the-art research… read more here.
Keywords: respiration metabolic; diseases overview; metabolic diseases; respiration ... See more keywords
Ursolic acid improves the indoxyl sulfate-induced impairment of mitochondrial biogenesis in C2C12 cells
Sign Up to like & getrecommendations! Published in 2022 at "Nutrition Research and Practice"
DOI: 10.4162/nrp.2022.16.2.147
Abstract: BACKGROUND/OBJECTIVES Patients with chronic kidney disease (CKD) have a high concentration of uremic toxins in their blood and often experience muscle atrophy. Indoxyl sulfate (IS) is a uremic toxin produced by tryptophan metabolism. Although an… read more here.
Keywords: c2c12 cells; induced impairment; impairment mitochondrial; mitochondrial biogenesis ... See more keywords