Hypermetabolism in the cerebellum and brainstem and cortical hypometabolism are independently associated with cognitive impairment in Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-018-4085-1
Abstract: PurposeCognitive impairment (CI) in Parkinson’s disease (PD) is associated with a widespread reduction in cortical glucose metabolism and relative increases in the cerebellum and brainstem as measured using 18F-fluorodesoxyglucose (FDG) PET. We separately analysed CI-related… read more here.
Keywords: index; hypometabolism; hypermetabolism; disease ... See more keywords
Cholinergic nucleus 4 atrophy and gait impairment in Parkinson’s disease
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DOI: 10.1007/s00415-020-10111-2
Abstract: Background There is evidence that cortical cholinergic denervation contributes to gait and balance impairment in Parkinson’s Disease (PD), especially reduced gait speed. Objectives The objective of this study was to determine the relationship between cholinergic… read more here.
Keywords: ch4 gmd; gmd associated; gmd; gait ... See more keywords
Extrastriatal 123I-FP-CIT SPECT impairment in Parkinson’s disease – the PPMI cohort
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DOI: 10.1186/s12883-020-01777-2
Abstract: Neuropathological data and nuclear medicine imaging show extensive serotonergic impairment in Parkinson’s disease (PD). We undertook a case-controlled analysis of 123I-FP-CIT SPECT images to measure extrastriatal serotonergic transporters (SERT) in PD using the Parkinson’s Progression… read more here.
Keywords: cit; impairment parkinson; 123i cit; cit spect ... See more keywords
A computer-based cognitive training in mild cognitive impairment in parkinson's disease.
Sign Up to like & getrecommendations! Published in 2019 at "NeuroRehabilitation"
DOI: 10.3233/nre-192714
Abstract: BACKGROUND There is no successful pharmacological treatment for cognitive impairment in Parkinson's Disease, therefore treatments capable of slowing down the progression of cognitive dysfunction are needed. OBJECTIVE To evaluate the effectiveness of a cognitive training,… read more here.
Keywords: cognitive training; mild cognitive; parkinson disease; impairment parkinson ... See more keywords
Miro1 Impairment in a Parkinson’s At-Risk Cohort
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2021.734273
Abstract: There is a lack of reliable molecular markers for Parkinson’s disease (PD) patients and at-risk individuals. The detection of the pre-symptomatic population of PD will empower more effective clinical intervention to delay or prevent disease… read more here.
Keywords: risk; risk individuals; miro1 impairment; cohort ... See more keywords