Huntingtin Aggregation Impairs Autophagy, Leading to Argonaute-2 Accumulation and Global MicroRNA Dysregulation.
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DOI: 10.1016/j.celrep.2018.07.017
Abstract: Many neurodegenerative diseases are characterized by the presence of intracellular protein aggregates, resulting in alterations in autophagy. However, the consequences of impaired autophagy for neuronal function remain poorly understood. In this study, we used cell… read more here.
Keywords: impairs autophagy; aggregation; accumulation; aggregation impairs ... See more keywords