Arsenic impairs GLUT1 trafficking through the inhibition of the calpain system in lymphocytes.
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DOI: 10.1016/j.taap.2019.114700
Abstract: Exposure to arsenic is associated with increased risk of developing insulin resistance and type 2 diabetes. The proteases calpain-1 (CAPN1), calpain-2 (CAPN2) and calpain-10 (CAPN10) and their endogenous inhibitor calpastatin (CAST) regulate glucose uptake in… read more here.
Keywords: calpain; glut1 trafficking; glucose uptake; impairs glut1 ... See more keywords