IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma
Sign Up to like & getrecommendations! Published in 2019 at "Nature cell biology"
DOI: 10.1038/s41556-019-0363-9
Abstract: In many cancers, high proliferation rates correlate with elevation of rRNA and tRNA levels, and nucleolar hypertrophy. However, the underlying mechanisms linking increased nucleolar transcription and tumorigenesis are only minimally understood. Here we show that… read more here.
Keywords: aberrant nucleolar; imp dehydrogenase; tumorigenesis; glioblastoma ... See more keywords
Investigation of IMPDH2 overexpression in renal cell carcinoma (RCC) & its association with oncologic outcomes.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.7_suppl.594
Abstract: 594 Background: Approximately 40% of locoregional RCC patients relapse after nephrectomy leading to lower 5 year survival rates of 53% (stage III) & 8% (metastatic). No biomarkers of prognostic significance are in clinical use at… read more here.
Keywords: rcc; oncologic outcomes; impdh2 overexpression; cell ... See more keywords
SARS-CoV-2 Nsp14 protein associates with IMPDH2 and activates NF-κB signaling
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1007089
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection leads to NF-κB activation and induction of pro-inflammatory cytokines, though the underlying mechanism for this activation is not fully understood. Our results reveal that the SARS-CoV-2 Nsp14… read more here.
Keywords: impdh2; nsp14 protein; cov nsp14; activation ... See more keywords