Abstract 4363062: BRCC3 inhibition of EndoMT via deubiquitination of Smad7: Implication in Atherosclerosis
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DOI: 10.1161/circ.152.suppl_3.4363062
Abstract: Background: Endothelial-to-mesenchymal transition (EndoMT), driven by the TGF-β/Smad2/3 signaling, contributes to endothelial dysfunction and atherosclerosis. BRCC3 is a K63-dependent deubiquitinase know to downregulate Smad pathways, but its role in EndoMT and atherosclerosis remains unclear. Objective:… read more here.
Keywords: endomt via; deubiquitination; implication atherosclerosis; atherosclerosis ... See more keywords