Disability and remote work during the pandemic with implications for cancer survivors
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cancer Survivorship"
DOI: 10.1007/s11764-021-01146-z
Abstract: Purpose This article examines the extent to which employees worked from home because of the pandemic, focusing on differentials between people with and without disabilities with implications for cancer survivors. Methods We use data on… read more here.
Keywords: cancer; implications cancer; cancer survivors; work ... See more keywords
Implications of cancer evolution for drug development
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Drug Discovery"
DOI: 10.1038/nrd.2017.78
Abstract: Tumour evolution, which results in the existence of multiple distinct populations of cancer cells within the same tumour and the same patient, is increasingly appreciated to have a key role in drug resistance. In this… read more here.
Keywords: drug; drug development; implications cancer; evolution ... See more keywords
The regulation of protein translation and its implications for cancer
Sign Up to like & getrecommendations! Published in 2021 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-020-00444-9
Abstract: In addition to the deregulation of gene transcriptions and post-translational protein modifications, the aberrant translation from mRNAs to proteins plays an important role in the pathogenesis of various cancers. Targeting mRNA translation are expected to… read more here.
Keywords: implications cancer; regulation protein; translation; protein translation ... See more keywords
p53 Isoforms and Their Implications in Cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cancers"
DOI: 10.3390/cancers10090288
Abstract: In this review we focus on the major isoforms of the tumor-suppressor protein p53, dysfunction of which often leads to cancer. Mutations of the TP53 gene, particularly in the DNA binding domain, have been regarded… read more here.
Keywords: implications cancer; isoforms implications; p53 isoforms; dna binding ... See more keywords
Role of Protein Kinases in Hedgehog Pathway Control and Implications for Cancer Therapy
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DOI: 10.3390/cancers11040449
Abstract: Hedgehog (HH) signaling is an evolutionarily conserved pathway that is crucial for growth and tissue patterning during embryonic development. It is mostly quiescent in the adult, where it regulates tissue homeostasis and stem cell behavior.… read more here.
Keywords: protein; implications cancer; protein kinases; cancer therapy ... See more keywords
Integrin Alpha v Beta 6 (αvβ6) and Its Implications in Cancer Treatment
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232012346
Abstract: Integrins are necessary for cell adhesion, migration, and positioning. Essential for inducing signalling events for cell survival, proliferation, and differentiation, they also trigger a variety of signal transduction pathways involved in mediating invasion, metastasis, and… read more here.
Keywords: beta; implications cancer; integrin alpha; cancer treatment ... See more keywords
Exosomes: Diagnostic and Therapeutic Implications in Cancer
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15051465
Abstract: Exosomes are a subset of extracellular vesicles produced by all cells, and they are present in various body fluids. Exosomes play crucial roles in tumor initiation/progression, immune suppression, immune surveillance, metabolic reprogramming, angiogenesis, and the… read more here.
Keywords: exosomes diagnostic; implications cancer; exosomal contents; therapeutic implications ... See more keywords