Human DNA helicase, RuvBL1 and its Chlamydomonas homologue, CrRuvBL1 plays an important role in ciliogenesis
Sign Up to like & getrecommendations! Published in 2017 at "Cytoskeleton"
DOI: 10.1002/cm.21377
Abstract: Several nuclear and nucleic acid‐binding proteins were detected in the proteomic analyses of ciliary fractions from various organisms. Yet very little is known about the role of these proteins in ciliogenesis and ciliary signaling. In… read more here.
Keywords: dna helicase; human dna; important role; role ciliogenesis ... See more keywords
Comprehensive Pharmacogenomic Study Reveals an Important Role of UGT1A3 in Montelukast Pharmacokinetics
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.891
Abstract: To identify the genetic basis of interindividual variability in montelukast exposure, we determined its pharmacokinetics and sequenced 379 pharmacokinetic genes in 191 healthy volunteers. An intronic single nucleotide variation (SNV), strongly linked with UGT1A3*2, associated… read more here.
Keywords: comprehensive pharmacogenomic; important role; auc0 montelukast; montelukast pharmacokinetics ... See more keywords
Cardiomyocyte dimethylarginine dimethylaminohydrolase-1 (DDAH1) plays an important role in attenuating ventricular hypertrophy and dysfunction
Sign Up to like & getrecommendations! Published in 2017 at "Basic Research in Cardiology"
DOI: 10.1007/s00395-017-0644-z
Abstract: Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthases that limits nitric oxide bioavailability. Dimethylarginine dimethylaminohydrolase-1 (DDAH1) exerts a critical role for ADMA degradation and plays an important role in NO signaling. In… read more here.
Keywords: plays important; dimethylarginine; ddah1; important role ... See more keywords
A potentially important role for T cells and regulatory T cells in Langerhans cell histiocytosis.
Sign Up to like & getrecommendations! Published in 2018 at "Clinical immunology"
DOI: 10.1016/j.clim.2018.06.004
Abstract: Langerhans cell histiocytosis is characterized by lesions containing inflammatory immune cells, including myeloid cells and T cells. Patient mortality remains unacceptably high and new treatment options are required. Several LCH studies have identified aberrant frequencies… read more here.
Keywords: langerhans cell; important role; regulatory cells; cell histiocytosis ... See more keywords
Contact micropredation may play a more important role than exotoxicity does in the lethal effects of Karlodinium australe blooms: Evidence from laboratory bioassays.
Sign Up to like & getrecommendations! Published in 2020 at "Harmful algae"
DOI: 10.1016/j.hal.2020.101926
Abstract: Multiple dinoflagellate species from the genus Karlodinium have been well known to form massive and toxic blooms that consequently cause fish kills in many coastal waters around the world. Karlodinium australe is a mixotrophic and… read more here.
Keywords: micropredation; karlodinium australe; lethal effects; important role ... See more keywords
The important role of Ga vacancies in the ferromagnetic GaN thin films
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Alloys and Compounds"
DOI: 10.1016/j.jallcom.2016.12.405
Abstract: Abstract Room-temperature ferromagnetism was observed in the unintentionally doped GaN films, which were fabricated using laser molecular beam epitaxy followed by annealing process at different temperatures from 800 to 1000 °C for 25 min in flowing nitrogen… read more here.
Keywords: role vacancies; temperature; important role; doped gan ... See more keywords
The amino terminal domain plays an important role in transjunctional voltage-dependent gating kinetics of Cx45 gap junctions.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2020.04.004
Abstract: Gap junction (GJ) channels formed by Cx45 exist in nodal cells in the heart where the action potential propagation is the slowest. The cellular mechanisms of slow propagation speed (or longer junctional delay) in nodal… read more here.
Keywords: voltage; gjs; important role; gating properties ... See more keywords
Important Role of Concave Surfaces in Deposition of Colloids under Favorable Conditions as Revealed by Microscale Visualization.
Sign Up to like & getrecommendations! Published in 2022 at "Environmental science & technology"
DOI: 10.1021/acs.est.1c07305
Abstract: This study conducted saturated column experiments to systematically investigate deposition of 1 μm positively charged polystyrene latex micro-colloids (representing microplastic particles) on negatively charged rough sand, glass beads, and soil with pore water velocities (PWV)… read more here.
Keywords: role concave; surfaces deposition; favorable conditions; important role ... See more keywords
mTORC1 plays an important role in osteoblastic regulation of B-lymphopoiesis
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-32858-5
Abstract: Skeletal osteoblasts are important regulators of B-lymphopoiesis, serving as a rich source of factors such as CXCL12 and IL-7 which are crucial for B-cell development. Recent studies from our laboratory and others have shown that… read more here.
Keywords: plays important; important role; mtorc1; mtorc1 plays ... See more keywords
Sugammadex: A Limited But Important Role in Emergency Medicine.
Sign Up to like & getrecommendations! Published in 2020 at "Pediatric emergency care"
DOI: 10.1097/01.pec.0000669932.22031.57
Abstract: Sugammadex reverses neuromuscular blockade by the steroidal nondepolarizing neuromuscular blocking agents rocuronium and vecuronium. In 2015, it was approved in the United States by the Food and Drug Administration for adult use. However, there are… read more here.
Keywords: medicine; use; important role; sugammadex ... See more keywords
Microglia: sculptors of neuropathic pain?
Sign Up to like & getrecommendations! Published in 2020 at "Royal Society Open Science"
DOI: 10.1098/rsos.200260
Abstract: Neuropathic pain presents a huge societal and individual burden. The limited efficacy of current analgesics, diagnostic markers and clinical trial outcome measures arises from an incomplete understanding of the underlying mechanisms. A large and growing… read more here.
Keywords: important role; nervous system; microglia sculptors; sculptors neuropathic ... See more keywords