Trypanosoma cruzi Importin α: ability to bind to a functional classical nuclear localization signal of the bipartite type.
Sign Up to like & getrecommendations! Published in 2020 at "Parasitology research"
DOI: 10.1007/s00436-020-06885-z
Abstract: Importin α, a transport factor in the classical pathway of nuclear transport of proteins in eukaryotes, has not been experimentally studied in trypanosomatids. A chimeric fluorescent version of this protein (TcImportin α-EGFP) expressed in transfected… read more here.
Keywords: nuclear localization; importin; ability; localization ... See more keywords
Targeting Nucleoporin POM121-Importin β Axis in Prostate Cancer.
Sign Up to like & getrecommendations! Published in 2018 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2018.09.003
Abstract: Nuclear pores are nanomachines acting as gatekeepers of molecular transport across nuclear membranes. In a recent issue of Cell, Rodriguez-Bravo et al. (2018) demonstrates that nuclear pores promote aggressive prostate cancer by snowballing POM121-importin β-driven nuclear import.… read more here.
Keywords: importin; pom121 importin; prostate cancer;
Characterization of the nuclear localization sequence of beak and feather disease virus capsid proteins and their assembly into virus-like particles.
Sign Up to like & getrecommendations! Published in 2020 at "Virus research"
DOI: 10.1016/j.virusres.2020.198144
Abstract: Beak and feather disease virus (BFDV) is a single-stranded circular DNA icosahedral virus that belongs to the Circoviridae family. This virus is the causative pathogen of beak and feather disease, which leads to feather loss,… read more here.
Keywords: cap; importin; cap proteins; feather disease ... See more keywords
Structural analysis of the complex between influenza B nucleoprotein and human importin-α
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-17458-z
Abstract: Influenza viruses are negative strand RNA viruses that replicate in the nucleus of the cell. The viral nucleoprotein (NP) is the major component of the viral ribonucleoprotein. In this paper we show that the NP… read more here.
Keywords: human importin; analysis complex; importin; influenza ... See more keywords
Structural characterization of human importin alpha 7 in its cargo-free form at 2.5 Å resolution
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-021-03729-3
Abstract: Shuttling of macromolecules between nucleus and cytoplasm is a tightly regulated process mediated through specific interactions between cargo and nuclear transport proteins. In the classical nuclear import pathway, importin alpha recognizes cargo exhibiting a nuclear… read more here.
Keywords: importin alpha; importin; alpha isoforms; cargo free ... See more keywords
Ibetazol, a novel inhibitor of importin β1-mediated nuclear import
Sign Up to like & getrecommendations! Published in 2024 at "Communications Biology"
DOI: 10.1038/s42003-024-07237-8
Abstract: Nucleocytoplasmatic transport plays an essential role in eukaryotic cell homeostasis and is mediated by karyopherins. Importin β1 (KPNB1) and its adaptor protein importin α1 (KPNA2) are the best-characterized karyopherins that effect nuclear import. Here, we… read more here.
Keywords: nuclear import; importin mediated; inhibitor importin; importin ... See more keywords
Structural and mechanistic insights into nuclear transport and delivery of the critical pluripotency factor Oct4 to DNA
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2017.1289124
Abstract: Oct4 is a master regulator of the induction and maintenance of cellular pluripotency, and has crucial roles in early stages of differentiation. It is the only factor that cannot be substituted by other members of… read more here.
Keywords: nuclear transport; importin; dna; delivery ... See more keywords
Importin α3 regulates chronic pain pathways in peripheral sensory neurons
Sign Up to like & getrecommendations! Published in 2020 at "Science"
DOI: 10.1126/science.aaz5875
Abstract: Nuclear transport controls chronic pain Chronic neuropathic pain is debilitating and difficult to treat. Marvaldi et al. now show that chronic pain is regulated by a specific nuclear import factor in peripheral sensory neurons (see… read more here.
Keywords: importin; peripheral sensory; sensory neurons; neuropathic pain ... See more keywords
NEMF mutations in mice illustrate how Importin-β specific nuclear transport defects recapitulate neurodegenerative disease hallmarks
Sign Up to like & getrecommendations! Published in 2024 at "PLOS Genetics"
DOI: 10.1371/journal.pgen.1011411
Abstract: Pathological disruption of Nucleocytoplasmic Transport (NCT), such as the mis-localization of nuclear pore complex proteins (Nups), nuclear transport receptors, Ran-GTPase, and RanGAP1, are seen in both animal models and in familial and sporadic forms of… read more here.
Keywords: disease; importin specific; transport; specific nuclear ... See more keywords
Importin α-importin β complex mediated nuclear translocation of insulin-like growth factor binding protein-5.
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DOI: 10.1507/endocrj.ej17-0156
Abstract: Insulin-like growth factor-binding protein (IGFBP)-5 is a secreted protein that binds to IGFs and modulates IGF actions, as well as regulates cell proliferation, migration, and apoptosis independent of IGF. Proper cellular localization is critical for… read more here.
Keywords: igfbp; importin; importin importin; igfbp nuclear ... See more keywords
Inhibition of Importin-α-mediated Nuclear Localization of Dendrin Attenuates Podocyte Loss and Glomerulosclerosis.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.0000000000000150
Abstract: BACKGROUND Nuclear translocation of dendrin is observed in the glomeruli in numerous human renal diseases, but the mechanism remains unknown. This study investigated that mechanism and its consequence in podocytes. METHODS The effect of dendrin… read more here.
Keywords: importin; podocyte loss; loss glomerulosclerosis; glomerulosclerosis ... See more keywords