Importin α/β and the tug of war to keep TDP‐43 in solution: quo vadis?
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202200181
Abstract: The transactivation response‐DNA binding protein of 43 kDa (TDP‐43) is an aggregation‐prone nucleic acid‐binding protein linked to the etiology of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Lobar Degeneration (FTLD). These conditions feature the accumulation of… read more here.
Keywords: tug war; aggregation; keep tdp; importin tug ... See more keywords