Mitotically Stable Modification of DNA Methylation in IGF2/H19 Imprinting Control Region Is Associated with Activated Hepatic IGF2 Expression in Offspring Rats from Betaine-Supplemented Dams.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.7b05418
Abstract: The growth-promoting action of betaine involves activation of GH/IGF-1 signaling, yet it remains unclear whether insulin-like growth factor 2 (IGF2), an imprinting gene, is affected by maternal dietary betaine supplementation. In this study, F1 offspring… read more here.
Keywords: imprinting control; hepatic igf2; offspring rats; betaine ... See more keywords
Epigenome editing reveals core DNA methylation for imprinting control in the Dlk1-Dio3 imprinted domain
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac344
Abstract: Abstract The Dlk1-Dio3 imprinted domain is controlled by an imprinting control region (ICR) called IG-DMR that is hypomethylated on the maternal allele and hypermethylated on the paternal allele. Although several genetic mutation experiments have shown… read more here.
Keywords: imprinting control; methylation; dna methylation; dlk1 dio3 ... See more keywords
Discovering candidate imprinted genes and imprinting control regions in the human genome
Sign Up to like & getrecommendations! Published in 2020 at "BMC Genomics"
DOI: 10.1186/s12864-020-6688-8
Abstract: Background Genomic imprinting is a process thereby a subset of genes is expressed in a parent-of-origin specific manner. This evolutionary novelty is restricted to mammals and controlled by genomic DNA segments known as Imprinting Control… read more here.
Keywords: imprinted genes; control regions; candidate; human genome ... See more keywords