Drug delivery for bioactive polysaccharides to improve their drug-like properties and curative efficacy
Sign Up to like & getrecommendations! Published in 2017 at "Drug Delivery"
DOI: 10.1080/10717544.2017.1396383
Abstract: Abstract Over several decades, natural polysaccharides (PSs) have been actively exploited for their wide bioactivities. So far, many PS-related reviews have been published; however, none focused on the delivery of bioactive PSs as therapeutic molecules.… read more here.
Keywords: delivery bioactive; drug delivery; delivery; pss ... See more keywords
Liposomes targeted to MHC-restricted antigen improve drug delivery and antimelanoma response
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s190736
Abstract: Purpose Melanoma is the most aggressive form of skin cancer. Chemotherapy at a late stage fails due to low accumulation in tumors, indicating the need for targeted therapy. Materials and methods To increase drug uptake… read more here.
Keywords: response; drug; drug delivery; tumor ... See more keywords
Covalently Targeted Highly Conserved Tyr318 to Improve the Drug Resistance Profiles of HIV-1 NNRTIs: A Proof-of-Concept Study
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24021215
Abstract: This study presents proof of concept for designing a novel HIV-1 covalent inhibitor targeting the highly conserved Tyr318 in the HIV-1 non-nucleoside reverse transcriptase inhibitors binding pocket to improve the drug resistance profiles. The target… read more here.
Keywords: proof concept; improve drug; highly conserved; conserved tyr318 ... See more keywords