Ten strategies to improve the efficacy of laparoscopic biliary surgery
Sign Up to like & getrecommendations! Published in 2020 at "Cirugia Espanola"
DOI: 10.1016/j.cireng.2020.10.009
Abstract: Laparoscopic surgery is the gold standard treatment of symptomatic gallstones. For some, it is also the treatment of choice for choledocholithiasis. Certain special and rare circumstances regarding the number, size and location of bile duct… read more here.
Keywords: laparoscopic; surgery; improve efficacy; efficacy laparoscopic ... See more keywords
Targeted Degradation of MDM2 as a New Approach to Improve the Efficacy of MDM2-p53 Inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b01945
Abstract: MDM2 is a key oncogenic protein that serves as a negative regulator of the tumor suppressor p53. While a number of inhibitors of the MDM2-p53 interaction have progressed to clinical testing as treatments for a… read more here.
Keywords: improve efficacy; mdm2 p53; targeted degradation;
Abstract CT059: Epigenetic tumor remodelling to improve the efficacy of immune checkpoint blockade: the NIBIT-M4 clinical trial
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-ct059
Abstract: Introduction: The anti-CTLA-4 monoclonal antibody (mAb) ipilimumab (Ipi) has firstly shown the therapeutic potential of targeting immune checkpoints in metastatic melanoma (MM) patients (pts), though with limited objective clinical responses, ranging from 10 to 13%… read more here.
Keywords: epigenetic tumor; blockade; efficacy; improve efficacy ... See more keywords
Managing the TME to improve the efficacy of cancer therapy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.954992
Abstract: The tumor microenvironment (TME) influences tumor growth, metastatic spread and response to treatment. Often immunosuppression, mediated by the TME, impairs a beneficial response. The complexity of the tumor composition challenges our abilities to design new… read more here.
Keywords: tme improve; improve efficacy; managing tme; tumor ... See more keywords
Novel Approaches to Improve the Efficacy of Immuno-Radiotherapy
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2019.00156
Abstract: Radiotherapy (RT) has been applied for decades as a treatment modality in the management of various types of cancer. Ionizing radiation induces tumor cell death, which in turn can either elicit protective anti-tumor immune responses… read more here.
Keywords: dna damage; novel approaches; radiotherapy; approaches improve ... See more keywords
Redesigning of Cell-Penetrating Peptides to Improve Their Efficacy as a Drug Delivery System
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14050907
Abstract: Cell-penetrating peptides (CPP) are promising tools for the transport of a broad range of compounds into cells. Since the discovery of the first members of this peptide family, many other peptides have been identified; nowadays,… read more here.
Keywords: cell; peptides improve; cell penetrating; improve efficacy ... See more keywords
Sex differences in hepatocellular carcinoma indicated BEX4 as a potential target to improve efficacy of lenvatinib plus immune checkpoint inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cancer"
DOI: 10.7150/jca.73051
Abstract: Background: Hepatocellular carcinoma (HCC) is the most common form of liver cancer, and significant sex disparities have been observed in HCC. We aim to explore the potential sex-biased mechanisms involved in hepatocarcinogenesis. Methods: Based on… read more here.
Keywords: hepatocellular carcinoma; immune checkpoint; hcc; improve efficacy ... See more keywords