Abstract 4652: Targeted nanomedicines improve therapeutic indices of RAF and MEK inhibitors
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-4652
Abstract: Potent kinase inhibitors have been developed to treat tumors, but they suppress signaling in normal cells so that their dosing and ability to inhibit the pathway are limited by toxicity, resulting in a narrow therapeutic… read more here.
Keywords: indices raf; therapeutic indices; targeted nanomedicines; improve therapeutic ... See more keywords
Tumor Targeted Nanoparticles Improve Therapeutic Index of BCL2 and MCL1 dual inhibition.
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DOI: 10.1182/blood.2020008017
Abstract: Cancer and normal cells utilize multiple anti-apoptotic BCL2 proteins to prevent cell death. Therapeutic targeting of multiple BCL2 family proteins enhances tumor killing, but is also associated with increased systemic toxicity. Here, we demonstrate that… read more here.
Keywords: nanoparticles improve; targeted nanoparticles; improve therapeutic; therapeutic index ... See more keywords