Glycopolymeric Nanoparticles Enrich Less Immunogenic Protein Coronas, Reduce Mononuclear Phagocyte Clearance, and Improve Tumor Delivery Compared to PEGylated Nanoparticles.
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DOI: 10.1021/acsnano.4c08922
Abstract: Nanoparticles (NPs) offer significant promise as drug delivery vehicles; however, their in vivo efficacy is often hindered by the formation of a protein corona (PC), which influences key physiological responses such as blood circulation time,… read more here.
Keywords: delivery; protein; tumor; improve tumor ... See more keywords
Synthetic Receptor-Based Targeting Strategies to Improve Tumor Drug Delivery.
Sign Up to like & getrecommendations! Published in 2021 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-021-01919-w
Abstract: Heterogeneity in tumor expression as well as expression in normal tissues of various targets limit the usefulness of current ligand-based active targeting approaches. Incorporation of synthetic receptors, which can be recognized by delivery systems engineered… read more here.
Keywords: receptor based; delivery; improve tumor; synthetic receptor ... See more keywords